{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:50:07Z","timestamp":1787010607916,"version":"build-2736575974"},"posted":{"date-parts":[[2024,11,8]]},"group-title":"Neuroscience","reference-count":116,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,11,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To systematically review and meta-analyze bulk RNA sequencing studies comparing Alzheimer\u2019s disease (AD) patients with controls in human brain tissue, assessing study quality and identifying key genes and pathways.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We searched PubMed, Web of Science, and Scopus on September 23, 2023, for studies using bulk RNAseq on primary human brain tissue from AD patients and controls. Excluded were non-primary tissue, re-analyses without new data, limited RNA types and gene panels. Quality was assessed with a 10-category tool. Meta-analysis used high-quality datasets.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From 3,266 records, 24 studies met criteria. Meta-analysis found 571 differentially expressed genes (DEGs) in temporal lobe and 189 in frontal lobe; overlapping pathways included \"Tube morphogenesis\" and \"Neuroactive ligand-receptor interaction.\"<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Limitations<\/jats:title>\n                  <jats:p>Study heterogeneity and limited data tables constrained the review.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Rigorous methods are vital in AD transcriptomic studies. Findings enhance understanding of transcriptomic changes, aiding biomarker and therapeutic development.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Registration<\/jats:title>\n                  <jats:p>PROSPERO (CRD42023466522).<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2024.11.07.622520","type":"posted-content","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T18:20:13Z","timestamp":1731090013000},"source":"Crossref","is-referenced-by-count":3,"title":["Systematic review and meta-analysis of bulk RNAseq studies in human Alzheimer\u2019s disease brain tissue"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6177-9316","authenticated-orcid":false,"given":"Bernardo Aguzzoli","family":"Heberle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin L.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-2262","authenticated-orcid":false,"given":"Lucas Lobraico","family":"Libermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4387-6430","authenticated-orcid":false,"given":"Sophia Ronchetti Martins","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8662-1847","authenticated-orcid":false,"given":"Guilherme Tarnowski","family":"Dallarosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-1631","authenticated-orcid":false,"given":"Rhan\u00e1 Carolina","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7207-4696","authenticated-orcid":false,"given":"David W.","family":"Fardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5446-1695","authenticated-orcid":false,"given":"Thiago Wendt","family":"Viola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9158-4440","authenticated-orcid":false,"given":"Mark T. 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