{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:28:25Z","timestamp":1773149305219,"version":"3.50.1"},"posted":{"date-parts":[[2024,11,13]]},"group-title":"Neurology","reference-count":42,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,11,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Early-onset restrictive eating disorders (rEO-ED) encompass a heterogeneous group of conditions, including early-onset anorexia nervosa (EO-AN) and avoidant restrictive food intake disorders (ARFID). Almost nothing is known about the consequences of rEO-ED on brain development.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed the largest comparison of MRI-derived brain features in children and early adolescents (&lt;13 years) with EO-AN (n=124), ARFID (n=50), and typically developing individuals (TD, n=112).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Despite similar body mass index (BMI) distributions, EO-AN and ARFID showed divergent structural patterns, suggesting independent brain mechanisms. Half the regional brain measures were correlated with BMI in EO-AN and none in ARFID, indicating a partial mediation of EO-AN signal by BMI. EO-AN was associated with a widespread pattern of thinner cortex, while underweight ARFID patients exhibited smaller surface area and subcortical volumes than TD.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>\n                    Future studies will be required to partition the contribution of low BMI\n                    <jats:italic>vs.<\/jats:italic>\n                    ED mechanisms in neurodevelopmental disorders.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2024.11.12.24317128","type":"posted-content","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T13:10:11Z","timestamp":1731503411000},"source":"Crossref","is-referenced-by-count":3,"title":["Neuroimaging Insights into Brain Mechanisms of Early-onset Restrictive Eating Disorders"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6217-731X","authenticated-orcid":false,"given":"Clara A.","family":"Moreau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3202-0781","authenticated-orcid":false,"given":"Anael","family":"Ayrolles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2921-3408","authenticated-orcid":false,"given":"Christopher R. 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