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Here, we successfully performed an unbiased distance-based analytic strategy on spatially-registered transcriptomic data. Leveraging immunohistochemistry in the same tissue section, our analyses prioritized\n                  <jats:italic>SERPINA3<\/jats:italic>\n                  and other genes, such as metallothioneins, as altered in the vicinity of neuritic amyloid plaques. Results were validated at the protein level by immunofluorescence, highlighting that a reactive SERPINA3\n                  <jats:sup>+<\/jats:sup>\n                  astrocyte subtype, Ast.5, plays a role in the plaque microenvironment.\n                <\/jats:p>","DOI":"10.1101\/2024.11.13.623438","type":"posted-content","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T23:50:19Z","timestamp":1731628219000},"source":"Crossref","is-referenced-by-count":8,"title":["Spatial Transcriptomic Analysis Identifies a\n                  <i>SERPINA3<\/i>\n                  -Expressing Astrocytic State Associated with the Human Neuritic Plaque 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