{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:47:43Z","timestamp":1768517263772,"version":"3.49.0"},"posted":{"date-parts":[[2024,12,9]]},"group-title":"Genetics","reference-count":63,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,3,29]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  To identify genes that regulate the response to the potentially addictive drug cocaine, we performed a control experiment using genome-wide association studies (GWASs) and RNA-Seq of a panel of inbred and recombinant inbred mice undergoing intravenous self-administration of saline. A linear mixed model increased statistical power for analysis of the longitudinal behavioral data, which was acquired over 10 days. A total of 145 loci were identified for saline compared to 17 for the corresponding cocaine GWAS. Only one locus overlapped. Transcriptome-wide association studies (TWASs) using RNA-Seq data from the nucleus accumbens and medial frontal cortex identified\n                  <jats:italic>5031434O11Rik<\/jats:italic>\n                  and\n                  <jats:italic>Zfp60<\/jats:italic>\n                  as significant for saline self-administration. Two other genes,\n                  <jats:italic>Myh4<\/jats:italic>\n                  and\n                  <jats:italic>Npc1<\/jats:italic>\n                  , were nominated based on proximity to loci for multiple endpoints or a\n                  <jats:italic>cis<\/jats:italic>\n                  locus regulating expression. All four genes have previously been implicated in locomotor activity, despite the absence of a strong relationship between saline taking and distance traveled in the open field. Our results indicate a distinct genetic basis for saline and cocaine self-administration, and suggest some common genes for saline self-administration and locomotor activity.\n                <\/jats:p>","DOI":"10.1101\/2024.12.04.626933","type":"posted-content","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T12:30:12Z","timestamp":1733747412000},"source":"Crossref","is-referenced-by-count":0,"title":["Differing genetics of saline and cocaine self-administration in the hybrid mouse diversity panel"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8725-3948","authenticated-orcid":false,"given":"Arshad H.","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9972-6498","authenticated-orcid":false,"given":"Jared R.","family":"Bagley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2394-8868","authenticated-orcid":false,"given":"Nathan","family":"LaPierre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-1393","authenticated-orcid":false,"given":"Carlos","family":"Gonzalez-Figueroa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2525-175X","authenticated-orcid":false,"given":"Tadeo C.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7557-4661","authenticated-orcid":false,"given":"Mudra","family":"Choudhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9362-8029","authenticated-orcid":false,"given":"Xinshu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1149-4758","authenticated-orcid":false,"given":"Eleazar","family":"Eskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6483-8844","authenticated-orcid":false,"given":"James D.","family":"Jentsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1215-3656","authenticated-orcid":false,"given":"Desmond J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2025040114000724000_2024.12.04.626933v2.1","doi-asserted-by":"publisher","DOI":"10.2147\/SAR.S337338"},{"key":"2025040114000724000_2024.12.04.626933v2.2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291721000969"},{"key":"2025040114000724000_2024.12.04.626933v2.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01256-1"},{"key":"2025040114000724000_2024.12.04.626933v2.4","first-page":"1","article-title":"Drug Overdose Deaths in the United States, 1999\u20132018","volume":"356","year":"2020","journal-title":"National Center for Health Statistics Data Briefs"},{"key":"2025040114000724000_2024.12.04.626933v2.5","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12738"},{"key":"2025040114000724000_2024.12.04.626933v2.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0008-x"},{"key":"2025040114000724000_2024.12.04.626933v2.7","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.110"},{"key":"2025040114000724000_2024.12.04.626933v2.8","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2019.1636384"},{"key":"2025040114000724000_2024.12.04.626933v2.9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-24740-2"},{"key":"2025040114000724000_2024.12.04.626933v2.10","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13162"},{"key":"2025040114000724000_2024.12.04.626933v2.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112856"},{"key":"2025040114000724000_2024.12.04.626933v2.12","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-012-9411-5"},{"key":"2025040114000724000_2024.12.04.626933v2.13","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15614"},{"key":"2025040114000724000_2024.12.04.626933v2.14","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R066944"},{"key":"2025040114000724000_2024.12.04.626933v2.15","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-5-43"},{"key":"2025040114000724000_2024.12.04.626933v2.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.12.007"},{"key":"2025040114000724000_2024.12.04.626933v2.17","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.11.1313"},{"key":"2025040114000724000_2024.12.04.626933v2.18","doi-asserted-by":"publisher","DOI":"10.1101\/gr.099234.109"},{"key":"2025040114000724000_2024.12.04.626933v2.19","unstructured":"S. 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