{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:17:34Z","timestamp":1768569454319,"version":"3.49.0"},"posted":{"date-parts":[[2024,12,16]]},"group-title":"Infectious Diseases (except HIV\/AIDS)","reference-count":30,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  This study investigated whole-cell oral cholera vaccine (kOCV) single-dose effectiveness and transmission dynamics of\n                  <jats:italic>Vibrio cholerae<\/jats:italic>\n                  through 4 years of epidemiological and genomic surveillance in Democratic Republic of the Congo (DRC). Whole genome sequencing was performed on clinical and water\n                  <jats:italic>V. cholerae<\/jats:italic>\n                  strains from 200 patient households and found annual bimodal peaks of\n                  <jats:italic>V. cholerae<\/jats:italic>\n                  clade AFR10e. 1154 diarrhea patients were enrolled with 342 culture confirmed cholera patients. A large clonal cholera outbreak occurred 18 months after a kOCV campaign of &gt;1 million doses of Euvichol-Plus, likely because of low vaccine coverage in informal settlements (9%). Clinical and water\n                  <jats:italic>V. cholerae<\/jats:italic>\n                  strains in the same household were more closely related than different households suggesting both person-to-person and water-to-person transmission. Single-dose kOCV vaccine effectiveness in the first 24 month after vaccination was 56.9% (95% CI: 18.6%-77.2%), suggesting a single-dose provided modest protection against medically attended cholera during the 24 months post-vaccination.\n                <\/jats:p>","DOI":"10.1101\/2024.12.16.24318874","type":"posted-content","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T03:27:16Z","timestamp":1734751636000},"source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of a single dose of oral cholera vaccine: findings from epidemiological and genomic surveillance of\n                  <i>Vibrio Cholerae<\/i>\n                  in the Democratic Republic of the Congo (PICHA7 Program)"],"prefix":"10.64898","author":[{"given":"Christine Marie","family":"George","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alves","family":"Namunesha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3427-298X","authenticated-orcid":false,"given":"Kelly","family":"Endres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willy","family":"Felicien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8240-2562","authenticated-orcid":false,"given":"Presence","family":"Sanvura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8906-7653","authenticated-orcid":false,"given":"Jean-Claude","family":"Bisimwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Perin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Bengehya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghislain","family":"Maheshe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cirhuza","family":"Cikomola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5570-5807","authenticated-orcid":false,"given":"Lucien","family":"Bisimwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8743-4295","authenticated-orcid":false,"given":"Alain","family":"Mwishingo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Sack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daryl","family":"Domman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"issue":"6","key":"2024122100415719000_2024.12.16.24318874v1.1","doi-asserted-by":"crossref","first-page":"e0003832","DOI":"10.1371\/journal.pntd.0003832","article-title":"Updated Global Burden of Cholera in Endemic Countries","volume":"9","year":"2015","journal-title":"PLoS neglected tropical diseases"},{"issue":"10133","key":"2024122100415719000_2024.12.16.24318874v1.2","first-page":"1908","article-title":"Mapping the burden of cholera in sub-Saharan Africa and implications for control: an analysis of data across geographical scales. 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