{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:52:20Z","timestamp":1782280340279,"version":"3.54.5"},"posted":{"date-parts":[[2024,12,20]]},"group-title":"Neuroscience","reference-count":61,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  SYNGAP1 is a major regulator of synaptic plasticity through its interaction with synaptic scaffold proteins and modulation of Ras and Rap GTPase signaling pathways.\n                  <jats:italic>SYNGAP1<\/jats:italic>\n                  mutations in humans are often associated with intellectual disability, epilepsy, and autism spectrum disorder.\n                  <jats:italic>Syngap1<\/jats:italic>\n                  heterozygous loss-of-function results in impaired LTP, premature maturation of dendritic spines, learning disabilities and seizures in mice. More recently, SYNGAP1 was shown to influence cortical neurogenesis and the proliferation of progenitors in human organoids. Here, we show that the absence or haploinsufficiency of\n                  <jats:italic>Syngap1<\/jats:italic>\n                  does not influence the properties of neocortical progenitors and their cellular output in mice. This discrepancy highlights potential species-specific or methodological differences and raises important questions about the broader applicability of SYNGAP1\u2019s role in neurogenesis.\n                <\/jats:p>","DOI":"10.1101\/2024.12.18.629233","type":"posted-content","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T03:55:33Z","timestamp":1734753333000},"source":"Crossref","is-referenced-by-count":2,"title":["Syngap1 and the development of murine neocortical progenitor cells"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-3002","authenticated-orcid":false,"given":"Soraia","family":"Bar\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7246-9233","authenticated-orcid":false,"given":"Ingie","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-5183","authenticated-orcid":false,"given":"Richard L.","family":"Huganir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025010304000699000_2024.12.18.629233v1.1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0420-19.2020"},{"key":"2025010304000699000_2024.12.18.629233v1.2","doi-asserted-by":"crossref","unstructured":"Jeyabalan, N. & Clement, J. P . SYNGAP1: Mind the Gap. Front Cell Neurosci 10, 32 (2016).","DOI":"10.3389\/fncel.2016.00032"},{"key":"2025010304000699000_2024.12.18.629233v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80471-7"},{"key":"2025010304000699000_2024.12.18.629233v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81008-9"},{"key":"2025010304000699000_2024.12.18.629233v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth783"},{"key":"2025010304000699000_2024.12.18.629233v1.6","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.D500009-MCP200"},{"key":"2025010304000699000_2024.12.18.629233v1.7","doi-asserted-by":"crossref","unstructured":"Sheng, M. & Kim, E . The postsynaptic organization of synapses. 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