{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:13:54Z","timestamp":1768518834716,"version":"3.49.0"},"posted":{"date-parts":[[2024,12,27]]},"group-title":"Neuroscience","reference-count":79,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,12,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Maternal stress during pregnancy, or prenatal stress, is a risk factor for neurodevelopmental disorders in offspring, including autism spectrum disorder (ASD). In ASD, dorsal striatum displays abnormalities correlating with symptom severity, but there is a gap in knowledge about dorsal striatal cellular and molecular mechanisms that may contribute. Using a mouse model, we investigated how prenatal stress impacted striatal-dependent behavior in adult offspring. We observed enhanced motor learning and earlier response times on an interval timing task, with accompanying changes in time-related medium spiny neuron (MSN) activity. We performed adult dorsal striatal single-cell RNA sequencing following prenatal stress which revealed differentially expressed genes (DEGs) in multiple cell types; downregulated DEGs were enriched for ribosome and translational pathways consistently in MSN subtypes, microglia, and somatostatin neurons. DEGs in MSN subtypes over-represented ASD risk genes and were enriched for synapse-related processes. These results provide insights into striatal alterations relevant to neurodevelopmental disorders.<\/jats:p>","DOI":"10.1101\/2024.12.27.627207","type":"posted-content","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T04:05:12Z","timestamp":1735358712000},"source":"Crossref","is-referenced-by-count":1,"title":["Long-term, cell type-specific effects of prenatal stress on dorsal striatum and relevant behaviors in mice"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3534-0817","authenticated-orcid":false,"given":"Maya M.","family":"Evans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9437-6118","authenticated-orcid":false,"given":"Benjamin W. Q.","family":"Hing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0488-1792","authenticated-orcid":false,"given":"Matthew A.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5945-5278","authenticated-orcid":false,"given":"Sara V.","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed I.","family":"Baig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3210-2098","authenticated-orcid":false,"given":"Grace S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha L.","family":"Anema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhett M.","family":"Ellerbroek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kartik","family":"Sivakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-0992","authenticated-orcid":false,"given":"Jacob J.","family":"Michaelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0427-0003","authenticated-orcid":false,"given":"Nandakumar S.","family":"Narayanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3906-0786","authenticated-orcid":false,"given":"Hanna E.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024123002000446000_2024.12.27.627207v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01198-w"},{"key":"2024123002000446000_2024.12.27.627207v1.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-019-01745-3"},{"key":"2024123002000446000_2024.12.27.627207v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.04.034"},{"key":"2024123002000446000_2024.12.27.627207v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2018.01.019"},{"key":"2024123002000446000_2024.12.27.627207v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2023.08.015"},{"key":"2024123002000446000_2024.12.27.627207v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2024.03.021"},{"key":"2024123002000446000_2024.12.27.627207v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(17)30049-4"},{"key":"2024123002000446000_2024.12.27.627207v1.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.09.040"},{"key":"2024123002000446000_2024.12.27.627207v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.10.029"},{"key":"2024123002000446000_2024.12.27.627207v1.10","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.577858"},{"key":"2024123002000446000_2024.12.27.627207v1.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.03.036"},{"key":"2024123002000446000_2024.12.27.627207v1.12","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-020-00624-2"},{"key":"2024123002000446000_2024.12.27.627207v1.13","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700054R"},{"key":"2024123002000446000_2024.12.27.627207v1.14","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02143-1"},{"key":"2024123002000446000_2024.12.27.627207v1.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102622"},{"key":"2024123002000446000_2024.12.27.627207v1.16","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0584-5"},{"key":"2024123002000446000_2024.12.27.627207v1.17","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01844-9"},{"key":"2024123002000446000_2024.12.27.627207v1.18","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00027"},{"key":"2024123002000446000_2024.12.27.627207v1.19","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22034"},{"key":"2024123002000446000_2024.12.27.627207v1.20","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00605-5"},{"key":"2024123002000446000_2024.12.27.627207v1.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.114114"},{"key":"2024123002000446000_2024.12.27.627207v1.22","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8227"},{"key":"2024123002000446000_2024.12.27.627207v1.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.04.023"},{"key":"2024123002000446000_2024.12.27.627207v1.24","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021656607278"},{"key":"2024123002000446000_2024.12.27.627207v1.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.028"},{"key":"2024123002000446000_2024.12.27.627207v1.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.11.096"},{"key":"2024123002000446000_2024.12.27.627207v1.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.02.030"},{"key":"2024123002000446000_2024.12.27.627207v1.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.06.059"},{"key":"2024123002000446000_2024.12.27.627207v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.06.021"},{"key":"2024123002000446000_2024.12.27.627207v1.30","doi-asserted-by":"publisher","DOI":"10.1101\/2024.05.17.594746"},{"key":"2024123002000446000_2024.12.27.627207v1.31","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02056-z"},{"key":"2024123002000446000_2024.12.27.627207v1.32","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.1017512"},{"key":"2024123002000446000_2024.12.27.627207v1.33","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.977305"},{"key":"2024123002000446000_2024.12.27.627207v1.34","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.19.3759"},{"key":"2024123002000446000_2024.12.27.627207v1.35","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1376-17.2017"},{"key":"2024123002000446000_2024.12.27.627207v1.36","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15344"},{"key":"2024123002000446000_2024.12.27.627207v1.37","doi-asserted-by":"publisher","DOI":"10.1101\/2023.07.25.550569"},{"key":"2024123002000446000_2024.12.27.627207v1.38","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05274-z"},{"key":"2024123002000446000_2024.12.27.627207v1.39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062811"},{"key":"2024123002000446000_2024.12.27.627207v1.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107540"},{"key":"2024123002000446000_2024.12.27.627207v1.41","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14576"},{"key":"2024123002000446000_2024.12.27.627207v1.42","doi-asserted-by":"publisher","DOI":"10.1101\/2024.01.09.574708"},{"key":"2024123002000446000_2024.12.27.627207v1.43","unstructured":"Verosky, D. C. , H. J.; Gur , T. L. in Neuroscience MeeCng Planner . Online (Society for Neuroscience)."},{"key":"2024123002000446000_2024.12.27.627207v1.44","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3907"},{"key":"2024123002000446000_2024.12.27.627207v1.45","doi-asserted-by":"publisher","DOI":"10.1037\/a0015640"},{"key":"2024123002000446000_2024.12.27.627207v1.46","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1270489"},{"key":"2024123002000446000_2024.12.27.627207v1.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.01.017"},{"key":"2024123002000446000_2024.12.27.627207v1.48","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13621"},{"key":"2024123002000446000_2024.12.27.627207v1.49","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-021-05129-y"},{"key":"2024123002000446000_2024.12.27.627207v1.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2024.03.011"},{"key":"2024123002000446000_2024.12.27.627207v1.51","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852920001571"},{"key":"2024123002000446000_2024.12.27.627207v1.52","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2022.902741"},{"key":"2024123002000446000_2024.12.27.627207v1.53","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7202a1"},{"key":"2024123002000446000_2024.12.27.627207v1.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.113967"},{"key":"2024123002000446000_2024.12.27.627207v1.55","doi-asserted-by":"publisher","DOI":"10.1101\/2023.01.31.526365"},{"key":"2024123002000446000_2024.12.27.627207v1.56","doi-asserted-by":"publisher","DOI":"10.1037\/bne0000577"},{"key":"2024123002000446000_2024.12.27.627207v1.57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2007.00348.x"},{"key":"2024123002000446000_2024.12.27.627207v1.58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1518316113"},{"key":"2024123002000446000_2024.12.27.627207v1.59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211258109"},{"key":"2024123002000446000_2024.12.27.627207v1.60","doi-asserted-by":"publisher","DOI":"10.1093\/texcom\/tgaa058"},{"key":"2024123002000446000_2024.12.27.627207v1.61","doi-asserted-by":"publisher","DOI":"10.1006\/meth.1999.0818"},{"key":"2024123002000446000_2024.12.27.627207v1.62","doi-asserted-by":"publisher","DOI":"10.1101\/2023.05.14.540705"},{"key":"2024123002000446000_2024.12.27.627207v1.63","unstructured":"RStudio: Integrated Development for R (RStudio, PBC, Boston, MA, 2020)."},{"key":"2024123002000446000_2024.12.27.627207v1.64","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa751"},{"key":"2024123002000446000_2024.12.27.627207v1.65","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.73600.2"},{"key":"2024123002000446000_2024.12.27.627207v1.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.053"},{"key":"2024123002000446000_2024.12.27.627207v1.67","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02146-6"},{"key":"2024123002000446000_2024.12.27.627207v1.68","doi-asserted-by":"publisher","DOI":"10.3390\/life12060850"},{"key":"2024123002000446000_2024.12.27.627207v1.69","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.005439"},{"key":"2024123002000446000_2024.12.27.627207v1.70","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01285-8"},{"key":"2024123002000446000_2024.12.27.627207v1.71","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.19090923"},{"key":"2024123002000446000_2024.12.27.627207v1.72","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12450-9"},{"key":"2024123002000446000_2024.12.27.627207v1.73","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02200-1"},{"key":"2024123002000446000_2024.12.27.627207v1.74","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1010"},{"key":"2024123002000446000_2024.12.27.627207v1.75","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00945-5"},{"key":"2024123002000446000_2024.12.27.627207v1.76","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz605"},{"key":"2024123002000446000_2024.12.27.627207v1.77","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1138"},{"key":"2024123002000446000_2024.12.27.627207v1.78","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"2024123002000446000_2024.12.27.627207v1.79","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac194"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2024.12.27.627207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:45:38Z","timestamp":1768463138000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2024.12.27.627207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":79,"URL":"https:\/\/doi.org\/10.1101\/2024.12.27.627207","relation":{},"subject":[],"published":{"date-parts":[[2024,12,27]]},"subtype":"preprint"}}