{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:00:19Z","timestamp":1783627219533,"version":"3.55.0"},"posted":{"date-parts":[[2025,1,15]]},"group-title":"Sexual and Reproductive Health","reference-count":26,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Human papillomavirus (HPV) is highly prevalent in adolescent girls and young women (AGYW) in sub-Saharan Africa. We evaluated short-term differences in HPV prevalence and early detection dynamics across hormonal contraceptive methods in AGYW.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Ninety-eight AGYW (15\u201319 years) were randomized to receive norethisterone enanthate (Net-EN), combined oral contraceptive pills (COCPs), or a combined contraceptive vaginal ring (CCVR). Cervical samples were collected at baseline and 16-weeks for HPV genotyping.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Baseline HPV prevalence was high (93\/98; 94.9%) and remained high at 16-weeks (87\/97; 89.5%), with no significant differences between contraceptive methods. Longitudinal analyses (n=87 paired samples) showed no statistically significant differences in HPV acquisition, persistence, or clearance.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>No significant differences were observed in HPV outcomes between hormonal contraceptive methods over 16-weeks. Findings should be interpreted as exploratory given the small sample size and short follow-up.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.01.14.25320519","type":"posted-content","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T12:15:16Z","timestamp":1736943316000},"source":"Crossref","is-referenced-by-count":1,"title":["Short-term HPV detection dynamics across hormonal contraceptive methods in adolescent girls and young women: a secondary analysis of a randomized trial in South Africa"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2650-8203","authenticated-orcid":false,"given":"Ramla F.","family":"Tanko","sequence":"first","affiliation":[{"name":"Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa"},{"name":"The Medical Research Centre, Institute of Medical Research and Medicinal Plant Studies (IMPM), Ministry of Scientific Research and Innovation, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4402-4891","authenticated-orcid":false,"given":"Ongeziwe","family":"Taku","sequence":"additional","affiliation":[{"name":"Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9073-4777","authenticated-orcid":false,"given":"Zizipho Z. A.","family":"Mbulawa","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Walter Sisulu University, Mthatha, Eastern Cape, South Africa"},{"name":"National Health Laboratory Service, Mthatha, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9413-5672","authenticated-orcid":false,"given":"Keletso","family":"Phohlo","sequence":"additional","affiliation":[{"name":"Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9566-6654","authenticated-orcid":false,"given":"Iyaloo","family":"Konstantinus","sequence":"additional","affiliation":[{"name":"Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa"},{"name":"Namibia Institute of Pathology, Windhoek, 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