{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:03:45Z","timestamp":1785578625292,"version":"3.56.0"},"posted":{"date-parts":[[2025,1,18]]},"group-title":"Immunology","reference-count":43,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,1,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Public health alarm concerning the emerging fungus\n                  <jats:italic>Candida auris<\/jats:italic>\n                  is fueled by its antifungal drug resistance and propensity to cause deadly outbreaks. Persistent skin colonization drives transmission and lethal sepsis although its basis remains mysterious. We compared the skin colonization dynamics of\n                  <jats:italic>C. auris<\/jats:italic>\n                  with its relative\n                  <jats:italic>C. albicans<\/jats:italic>\n                  , quantifying skin fungal persistence and distribution and immune composition and positioning.\n                  <jats:italic>C. auris<\/jats:italic>\n                  displayed a higher propensity to colonize hair follicles and avidly bound to human hair. While\n                  <jats:italic>C. albicans<\/jats:italic>\n                  triggered an effective sterilizing type 3\/17 antifungal immune response driven by IL-17A\/F-producing lymphocytes,\n                  <jats:italic>C. auris<\/jats:italic>\n                  triggered a type 1, IFN\u03b3-driven immune response targeting hair follicles. Rather than promoting fungal clearance, IFN\u03b3 enhanced\n                  <jats:italic>C. auris<\/jats:italic>\n                  skin colonization by acting directly on keratinocytes impairing epithelial barrier integrity and repressing antifungal defense programs.\n                  <jats:italic>C. auris<\/jats:italic>\n                  exploits focal skin immune responses to create a niche for persistence in hair follicles.\n                <\/jats:p>","DOI":"10.1101\/2025.01.15.632653","type":"posted-content","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T07:20:13Z","timestamp":1737184813000},"source":"Crossref","is-referenced-by-count":4,"title":["The emerging fungal pathogen\n                  <i>Candida auris<\/i>\n                  induces IFN\u03b3 to colonize mammalian hair follicles"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7175-5046","authenticated-orcid":false,"given":"Eric Dean","family":"Merrill","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of California, San Francisco; San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Prudent","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, University of California, San Francisco; San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parna","family":"Moghadam","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Saint Louis, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abram","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of California, San Francisco; San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Hurabielle","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of California, San Francisco; San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina K.C.","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of California, San Francisco; San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Basso","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, University of California, San Francisco; San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany C.","family":"Scharschmidt","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, San Francisco; San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Rosenblum","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, San Francisco; San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0764-3175","authenticated-orcid":false,"given":"Ari B.","family":"Molofsky","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of California, San Francisco; San Francisco, CA, USA"},{"name":"Biomedical Sciences Graduate Program, University of California, San Francisco; San Francisco, CA, USA"},{"name":"Diabetes Center, University of California, San Francisco; San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne M.","family":"Noble","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, University of California, San Francisco; San Francisco, CA, USA"},{"name":"Biomedical Sciences Graduate Program, University of California, San Francisco; San Francisco, CA, USA"},{"name":"Division of Infectious Diseases, Department of Medicine, University of California, San Francisco; San Francisco, CA, USA"},{"name":"Tetrad Graduate Program, University of California, San Francisco; San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026041021474306000_2025.01.15.632653v1.1","unstructured":"WHO fungal priority pathogens list to guide research, development and public health action. https:\/\/www.who.int\/publications\/i\/item\/9789240060241."},{"key":"2026041021474306000_2025.01.15.632653v1.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2008.00083.x"},{"key":"2026041021474306000_2025.01.15.632653v1.3","unstructured":"Antibiotic Resistance Coordination and Strategy Unit, D. o. 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