{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:58:43Z","timestamp":1782280723336,"version":"3.54.5"},"posted":{"date-parts":[[2025,1,17]]},"group-title":"Neuroscience","reference-count":90,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,1,17]]},"abstract":"<jats:title>\n                  A\n                  <jats:sc>bstract<\/jats:sc>\n                <\/jats:title>\n                <jats:p>Temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) is associated with a complex genetic architecture, but the translation from genetic risk factors to brain vulnerability remains unclear. Here, we examined associations between epilepsy-related polygenic risk scores for HS (PRS-HS) and brain structure in a large sample of neurotypical children, and correlated these signatures with case-control findings in in multicentric cohorts of patients with TLE-HS. Imaging-genetic analyses revealed PRS-related cortical thinning in temporo-parietal and fronto-central regions, strongly anchored to distinct functional and structural network epicentres. Compared to disease-related effects derived from epilepsy case-control cohorts, structural correlates of PRS-HS mirrored atrophy and epicentre patterns in patients with TLE-HS. By identifying a potential pathway between genetic vulnerability and disease mechanisms, our findings provide new insights into the genetic underpinnings of structural alterations in TLE-HS and highlight potential imaging-genetic biomarkers for early risk stratification and personalized interventions.<\/jats:p>","DOI":"10.1101\/2025.01.17.633277","type":"posted-content","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T03:45:25Z","timestamp":1737171925000},"source":"Crossref","is-referenced-by-count":0,"title":["Associations between epilepsy-related polygenic risk and brain morphology in childhood"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8999-9388","authenticated-orcid":false,"given":"Alexander","family":"Ngo","sequence":"first","affiliation":[{"name":"Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada"},{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Cabada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0348-2258","authenticated-orcid":false,"given":"Lang","family":"Liu","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada"},{"name":"Department of Human Genetics, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5701-1307","authenticated-orcid":false,"given":"Sara","family":"Larivi\u00e8re","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHUS, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1707-7437","authenticated-orcid":false,"given":"Valeria","family":"Kebets","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada"},{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Cabada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Fett","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada"},{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Cabada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0836-8833","authenticated-orcid":false,"given":"Clara F.","family":"Weber","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada"},{"name":"Department of Psychiatry and Psychotherapy, University of L\u00fcbeck, L\u00fcbeck, Germany"},{"name":"Centre of Brain, Behavior and Metabolism, University of L\u00fcbeck, L\u00fcbeck, 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