{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:53:06Z","timestamp":1775886786581,"version":"3.50.1"},"posted":{"date-parts":[[2025,1,23]]},"group-title":"Genetics","reference-count":39,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Oculocutaneous albinism (OCA) is a group of genetic disorders characterized by impaired melanin production, leading to reduced pigmentation in the skin, hair, and eyes.\n                  <jats:italic>Xiphophorus<\/jats:italic>\n                  , a genus of small freshwater fish, has been a pivotal model organism in pigmentation disorder research, providing key findings in the genetic pathways governing physiological and pathological pigment cell biology. Leveraging the well-established research framework provided by\n                  <jats:italic>Xiphophorus<\/jats:italic>\n                  , we have identified a spontaneously occurring albinism phenotype in swordtail fish\n                  <jats:italic>Xiphophorus hellerii<\/jats:italic>\n                  . Genetic mapping of albino fish showed that albinism is associated with a recessive mutation in the\n                  <jats:italic>oca2<\/jats:italic>\n                  gene. This discovery provides a novel opportunity to explore functions of\n                  <jats:italic>oca2<\/jats:italic>\n                  gene in pigment cell differentiation, pigment synthesis, melanosome assembly and transportation function and amelanotic melanoma development.\n                <\/jats:p>","DOI":"10.1101\/2025.01.20.633999","type":"posted-content","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T06:30:22Z","timestamp":1737613822000},"source":"Crossref","is-referenced-by-count":0,"title":["A Recessive\n                  <i>oca2<\/i>\n                  Mutation Underlies Albinism in\n                  <i>Xiphophorus<\/i>\n                  fish"],"prefix":"10.64898","author":[{"given":"Yanting","family":"Xing","sequence":"first","affiliation":[{"name":"Institute for Molecular Life Sciences, Texas State University, San Marcos, TX, 78666"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Boswell","sequence":"additional","affiliation":[{"name":"Institute for Molecular Life Sciences, Texas State University, San Marcos, TX, 78666"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Parker","sequence":"additional","affiliation":[{"name":"Institute for Molecular Life Sciences, Texas State University, San Marcos, TX, 78666"},{"name":"Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, 78666"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Du","sequence":"additional","affiliation":[{"name":"Institute for Molecular Life Sciences, Texas State University, San Marcos, TX, 78666"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Schartl","sequence":"additional","affiliation":[{"name":"Institute for Molecular Life Sciences, Texas State University, San Marcos, TX, 78666"},{"name":"Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, 78666"},{"name":"Developmental Biochemistry, Biocenter, University of W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"Research Department for Limnology, University of Innsbruck, Mondsee, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute for Molecular Life Sciences, Texas State University, San Marcos, TX, 78666"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026041022280762000_2025.01.20.633999v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/1357-4310(96)81798-9"},{"key":"2026041022280762000_2025.01.20.633999v1.2","first-page":"e905472","article-title":"Mutational Analysis of Oculocutaneous Albinism: A Compact Review","volume":"2014","year":"2014","journal-title":"BioMed Res. 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