{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:50:32Z","timestamp":1768567832995,"version":"3.49.0"},"posted":{"date-parts":[[2025,1,24]]},"group-title":"Cardiovascular Medicine","reference-count":34,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Heart failure (HF) and atrial fibrillation (AF) are closely linked, each exacerbating the other. While sodium-glucose cotransporter-2 inhibitors (SGLT2i) are known to provide substantial benefits in HF management, their effect on AF incidence in this population is not well-defined.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aims to assess the effect of SGLT2i therapy on the development of new-onset AF in patients with HF.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective analysis included all patients hospitalized with a primary diagnosis of HF and no prior diagnosis of AF over a 3-year period. The primary outcome was the occurrence of new-onset AF within 12 months following HF hospitalization.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    Of 3,953 patients 720 (18.2%) developed AF within one year. SGLT2i use was associated with significantly lower risk of AF (\n                    <jats:italic>HR 0.69, 95% CI:0.55-0.87; p=0.002<\/jats:italic>\n                    ) across all HF types-reduced, mid-range, and preserved ejection fraction. Kaplan-Meier survival analysis revealed significantly reduced AF-free survival in patients not on SGLT2i therapy, compared to patients on SGLT2i therapy, across subgroups categorized by diabetes, hypertension, coronary artery disease, age \u226565 years, and BMI \u226530Kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    (p &lt;0.05 for all). Among those who developed AF, SGLT2i use had significantly lower incidence of AF during follow-up as compared to when not used (12.1% vs. 19.5%, p&lt;0.001). SGLT2 use also delayed onset of AF compared to those not treated with an SGLT2i (339 \u00b1 80 days vs. 317 \u00b1 106 days;\n                    <jats:italic>p&lt;0.001<\/jats:italic>\n                    ).\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The use of SGLT2i therapy is associated with a significantly lower risk of the developing AF following hospitalization for HF.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.01.21.25320931","type":"posted-content","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T13:55:13Z","timestamp":1737726913000},"source":"Crossref","is-referenced-by-count":0,"title":["The impact of SGLT-2 Inhibitors on the Risk of Atrial Fibrillation in Heart Failure"],"prefix":"10.64898","author":[{"given":"Thomas","family":"Fretz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2038-7786","authenticated-orcid":false,"given":"Onyedika","family":"Ilonze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2664-6961","authenticated-orcid":false,"given":"Tanyanan","family":"Tanawuttiwat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithilesh 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