{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:04:37Z","timestamp":1782281077361,"version":"3.54.5"},"posted":{"date-parts":[[2025,1,23]]},"group-title":"Neuroscience","reference-count":84,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Mild traumatic brain injury (mTBI) is common in adolescents. Magnetoencephalography (MEG) studies (primarily reporting on adult males) have demonstrated abnormal resting-state (RS) brain activity in mTBI. The present study sought to identify RS abnormalities in male and female adolescents with mTBI (no previous mTBI and no previous DSM-5 diagnosis) identified from an outpatient specialty care concussion program setting as a basis for evaluating potential clinical utility. Visit 1 MEG RS data were obtained from 46 adolescents with mTBI (mean age: 15.4 years, 25 females) within 4 months of a mTBI (mTBI acute to sub-acute period) as well as from 34 typically developing (TD) controls (mean age: 14.8 years; 17 females) identified from the local community. Visit 2 RS data (follow-up \u223c4.3 months after Visit 1; mTBI sub-chronic period) were obtained from 36 mTBI (19 females) and 29 TD (14 females) of those participants. Source-space RS neural activity was examined from 4 to 56 Hz. Visit 1 t-tests showed that group differences were largest in the beta range (16-30 Hz; mTBI &lt; TD), with Visit 2 whole-brain linear mixed model (LMM) analyses examining beta-band group differences as a function of Visit. A main effect of Group indicated Visit 1 and 2 beta-band group differences in midline superior frontal gyrus, right temporal pole, and right central sulcus (all mTBI &lt; TD). The group effects were large (Cohen\u2019s\n                  <jats:italic>d<\/jats:italic>\n                  values 0.75 to 1.31). Of clinical significance in the mTBI group, a decrease in mTBI symptoms from Visit 1 to 2 was associated with an increase in beta power in 4 other brain regions. Present findings suggest that RS beta power has potential as a measure and perhaps as a mechanism of clinical recovery in adolescents with mTBI.\n                <\/jats:p>","DOI":"10.1101\/2025.01.22.633765","type":"posted-content","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T23:35:37Z","timestamp":1737761737000},"source":"Crossref","is-referenced-by-count":0,"title":["Regionally specific resting-state beta neural power predicts brain injury and symptom recovery in adolescents with concussion: a longitudinal study"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6731-5443","authenticated-orcid":false,"given":"J. Christopher","family":"Edgar","sequence":"first","affiliation":[{"name":"Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Department of Radiology, Perelman School of Medicine, University of Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Blaskey","sequence":"additional","affiliation":[{"name":"Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Department of Radiology, Perelman School of Medicine, University of Pennsylvania."},{"name":"Center for Autism Research, Department of Pediatrics, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Chen","sequence":"additional","affiliation":[{"name":"Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia E.","family":"Podolak","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drayton L.","family":"Murray","sequence":"additional","affiliation":[{"name":"Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Department of Radiology, Perelman School of Medicine, University of Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marybeth","family":"McNamee","sequence":"additional","affiliation":[{"name":"Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Konka","sequence":"additional","affiliation":[{"name":"Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey I.","family":"Berman","sequence":"additional","affiliation":[{"name":"Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Department of Radiology, Perelman School of Medicine, University of Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P.L.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Department of Radiology, Perelman School of Medicine, University of Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1694-4562","authenticated-orcid":false,"given":"Kristy B.","family":"Arbogast","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Prevention, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA,"},{"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina L.","family":"Master","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Prevention, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA,"},{"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026041022422426000_2025.01.22.633765v1.1","doi-asserted-by":"publisher","DOI":"10.1097\/00001199-200609000-00001"},{"key":"2026041022422426000_2025.01.22.633765v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52892-6.00001-5"},{"key":"2026041022422426000_2025.01.22.633765v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.01.039"},{"key":"2026041022422426000_2025.01.22.633765v1.4","doi-asserted-by":"publisher","DOI":"10.1177\/0009922815594367"},{"key":"2026041022422426000_2025.01.22.633765v1.5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.1203"},{"key":"2026041022422426000_2025.01.22.633765v1.6","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0b013e31827f5f93"},{"key":"2026041022422426000_2025.01.22.633765v1.7","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2017-097699"},{"key":"2026041022422426000_2025.01.22.633765v1.8","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.190"},{"key":"2026041022422426000_2025.01.22.633765v1.9","doi-asserted-by":"publisher","DOI":"10.3171\/JNS\/2008\/108\/3\/0511"},{"key":"2026041022422426000_2025.01.22.633765v1.10","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000166663.98616.E4"},{"key":"2026041022422426000_2025.01.22.633765v1.11","unstructured":"Anonymous (2014) Sports-Related Concussions in Youth: Improving the Science, Changing the Culture, The National Academies Collection: Reports funded by National Institutes of Health, eds Graham R , Rivara FP , Ford MA , & Spicer CMWashington (DC))."},{"key":"2026041022422426000_2025.01.22.633765v1.12","doi-asserted-by":"publisher","DOI":"10.3928\/00904481-20120426-10"},{"key":"2026041022422426000_2025.01.22.633765v1.13","first-page":"35","article-title":"Chronic Post-Concussion Neurocognitive Deficits","volume":"10","year":"2016","journal-title":"I. Relationship with White Matter Integrity. Front Hum Neurosci"},{"key":"2026041022422426000_2025.01.22.633765v1.14","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3395"},{"key":"2026041022422426000_2025.01.22.633765v1.15","doi-asserted-by":"crossref","unstructured":"Bigler ED , Orrison, W.W. (2004) Neuroimaging in sports-related brain injury. Traumatic brain injury in sports: An international perspective, ed Lovell MR , Echemendia, R.J. , Barth, J.T. , Collins, M.W. (Swets and Zetlinger, Lisse, Netherlands), pp 71\u201394.","DOI":"10.1201\/9780367810535-5"},{"key":"2026041022422426000_2025.01.22.633765v1.16","doi-asserted-by":"publisher","DOI":"10.1097\/00042752-200107000-00007"},{"key":"2026041022422426000_2025.01.22.633765v1.17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0994"},{"key":"2026041022422426000_2025.01.22.633765v1.18","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0b013e3181e52c2a"},{"issue":"4","key":"2026041022422426000_2025.01.22.633765v1.19","first-page":"699","article-title":"Head trauma: comparison of MR and CT--experience in 100 patients","volume":"9","year":"1988","journal-title":"AJNR Am J Neuroradiol"},{"key":"2026041022422426000_2025.01.22.633765v1.20","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199602000-00002"},{"key":"2026041022422426000_2025.01.22.633765v1.21","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0000000000000071"},{"key":"2026041022422426000_2025.01.22.633765v1.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-4694(98)00057-1"},{"key":"2026041022422426000_2025.01.22.633765v1.23","doi-asserted-by":"publisher","DOI":"10.1097\/01.HTR.0000271115.29954.27"},{"issue":"5","key":"2026041022422426000_2025.01.22.633765v1.24","first-page":"857","article-title":"Neuromagnetic assessment of pathophysiologic brain activity induced by minor head trauma","volume":"20","year":"1999","journal-title":"AJNR Am J Neuroradiol"},{"key":"2026041022422426000_2025.01.22.633765v1.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102697"},{"key":"2026041022422426000_2025.01.22.633765v1.26","first-page":"1","article-title":"Magnetoencephalography in the Detection and Characterization of Brain Abnormalities Associated with Traumatic Brain Injury: A Comprehensive Review","volume":"9","year":"2021","journal-title":"Med Sci (Basel)"},{"key":"2026041022422426000_2025.01.22.633765v1.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2016.02.002"},{"key":"2026041022422426000_2025.01.22.633765v1.28","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1506-15.2016"},{"key":"2026041022422426000_2025.01.22.633765v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.02.020"},{"key":"2026041022422426000_2025.01.22.633765v1.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2016.06.004"},{"key":"2026041022422426000_2025.01.22.633765v1.31","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00333.2020"},{"key":"2026041022422426000_2025.01.22.633765v1.32","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2008.0672"},{"key":"2026041022422426000_2025.01.22.633765v1.33","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00280"},{"key":"2026041022422426000_2025.01.22.633765v1.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.09.011"},{"key":"2026041022422426000_2025.01.22.633765v1.35","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4581"},{"key":"2026041022422426000_2025.01.22.633765v1.36","unstructured":"Foss LJ, Belli , A., Brody , D.L., Brookes , M.J., Bull , A.M.J., Craner , M., Dunkley , B.T., Evangelou , N., Furlong , P.L., Gibb , I., Goldstone , A.P., Green , G., Hettiaratchy , S., Hodgetts , T.J., Lee , R.R., Mistlin , A., Nader , K., Perl , D., Reid , A.N.C., Scadding , J.W., Seri, S. , Sharp, D.J. , Sherwood, D. , Simms, A. , Sinclair, A.J. , Wessely, S. , Wilde, E.A. , Woods, D.R. (2020) Setting a National Consensus for Managing Mild and Blast Traumatic Brain Injury: Post-Meeting Consensus Report (Imperial College, London, UK)."},{"issue":"2","key":"2026041022422426000_2025.01.22.633765v1.37","doi-asserted-by":"crossref","first-page":"fcab044","DOI":"10.1093\/braincomms\/fcab044","article-title":"Mild traumatic brain injury is associated with dysregulated neural network functioning in children and adolescents","volume":"3","year":"2021","journal-title":"Brain Commun"},{"key":"2026041022422426000_2025.01.22.633765v1.38","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2720"},{"key":"2026041022422426000_2025.01.22.633765v1.39","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2022.0220"},{"key":"2026041022422426000_2025.01.22.633765v1.40","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2019.6417"},{"key":"2026041022422426000_2025.01.22.633765v1.41","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2018.00521"},{"key":"2026041022422426000_2025.01.22.633765v1.42","doi-asserted-by":"publisher","DOI":"10.1177\/1559827614538751"},{"key":"2026041022422426000_2025.01.22.633765v1.43","unstructured":"Gadow KD , Sprafkin, J. (2010) Child and Adolescent Symptom Inventory 4R: Screening and norms manual (Checkmate Plus, Stony Brook, NY)."},{"key":"2026041022422426000_2025.01.22.633765v1.44","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acu014"},{"key":"2026041022422426000_2025.01.22.633765v1.45","unstructured":"Achenbach TME (1983) Manual for child behavior checklist and revised behavior profile (University of Vermont, Burlington, VT)."},{"key":"2026041022422426000_2025.01.22.633765v1.46","doi-asserted-by":"crossref","unstructured":"Kovacs M (2011) Children\u2019s Depression Inventory, 2nd Edition. (Multi-Heath Systems, Inc., North Tonawanda, New York).","DOI":"10.1037\/t04948-000"},{"key":"2026041022422426000_2025.01.22.633765v1.47","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199704000-00018"},{"key":"2026041022422426000_2025.01.22.633765v1.48","doi-asserted-by":"publisher","DOI":"10.1007\/s10578-018-0854-0"},{"key":"2026041022422426000_2025.01.22.633765v1.49","doi-asserted-by":"crossref","unstructured":"Gioia GA , Isquith, P. K. , Guy, S.C. , Kenworthy, L. (2015) Behavior Rating Inventory of Executive Function, Second Edition (BRIEF-2) (Psychological Assessment Resources, Odessa, FL).","DOI":"10.1037\/t79467-000"},{"key":"2026041022422426000_2025.01.22.633765v1.50","unstructured":"Sattler JM , Dunmont, R. , and Coalson, D. (2016) Assessment of Children: WICS-V and WPPSI-IV (Jerome Sattler, Publisher, Inc., LaMesa, CA)."},{"key":"2026041022422426000_2025.01.22.633765v1.51","doi-asserted-by":"crossref","unstructured":"Delis DC , Kaplan, E. , Kramer, J.H. (2001) Delis-Kaplan Executive Function System (Pearson, San Antonio, TX).","DOI":"10.1037\/t15082-000"},{"key":"2026041022422426000_2025.01.22.633765v1.52","unstructured":"Schmidt M (1996) Rey Auditory and Verbal Learning Test. A handbook (Western Psychological Association, Los Angeles)."},{"key":"2026041022422426000_2025.01.22.633765v1.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.04.055"},{"key":"2026041022422426000_2025.01.22.633765v1.54","doi-asserted-by":"publisher","DOI":"10.1023\/B:BRAT.0000032857.55223.5d"},{"key":"2026041022422426000_2025.01.22.633765v1.55","doi-asserted-by":"publisher","DOI":"10.1007\/BF01128700"},{"key":"2026041022422426000_2025.01.22.633765v1.56","first-page":"127","article-title":"New concepts of brain source imaging and localization","volume":"46","year":"1996","journal-title":"Electroencephalogr Clin Neurophysiol Suppl"},{"key":"2026041022422426000_2025.01.22.633765v1.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.09.022"},{"key":"2026041022422426000_2025.01.22.633765v1.58","doi-asserted-by":"publisher","DOI":"10.1109\/10.16463"},{"key":"2026041022422426000_2025.01.22.633765v1.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.04.029"},{"key":"2026041022422426000_2025.01.22.633765v1.60","doi-asserted-by":"publisher","DOI":"10.2307\/2346101"},{"key":"2026041022422426000_2025.01.22.633765v1.61","unstructured":"Anonymous (2021) Principles of Neural Science, Sixth Edition (McGraw-Hill Education, New York)."},{"key":"2026041022422426000_2025.01.22.633765v1.62","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07094.x"},{"key":"2026041022422426000_2025.01.22.633765v1.63","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21478"},{"key":"2026041022422426000_2025.01.22.633765v1.64","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23006"},{"key":"2026041022422426000_2025.01.22.633765v1.65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000479"},{"key":"2026041022422426000_2025.01.22.633765v1.66","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608587113"},{"key":"2026041022422426000_2025.01.22.633765v1.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.04.029"},{"key":"2026041022422426000_2025.01.22.633765v1.68","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-015-0545-1"},{"key":"2026041022422426000_2025.01.22.633765v1.69","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604135113"},{"key":"2026041022422426000_2025.01.22.633765v1.70","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-017-9684-0"},{"key":"2026041022422426000_2025.01.22.633765v1.71","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000491"},{"key":"2026041022422426000_2025.01.22.633765v1.72","doi-asserted-by":"crossref","unstructured":"Mahjoory K , Schoffelen JM , Keitel A , & Gross J (2020) The frequency gradient of human resting-state brain oscillations follows cortical hierarchies. Elife 9.","DOI":"10.7554\/eLife.53715"},{"key":"2026041022422426000_2025.01.22.633765v1.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2017.11.002"},{"key":"2026041022422426000_2025.01.22.633765v1.74","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz087"},{"key":"2026041022422426000_2025.01.22.633765v1.75","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-018-0667-2"},{"key":"2026041022422426000_2025.01.22.633765v1.76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004914"},{"key":"2026041022422426000_2025.01.22.633765v1.77","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102841"},{"key":"2026041022422426000_2025.01.22.633765v1.78","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24989"},{"key":"2026041022422426000_2025.01.22.633765v1.79","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211008596"},{"key":"2026041022422426000_2025.01.22.633765v1.80","doi-asserted-by":"publisher","DOI":"10.4085\/1062-6050-46.1.76"},{"key":"2026041022422426000_2025.01.22.633765v1.81","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0000000000000646"},{"key":"2026041022422426000_2025.01.22.633765v1.82","doi-asserted-by":"publisher","DOI":"10.1523\/eneuro.0235-20.2020"},{"key":"2026041022422426000_2025.01.22.633765v1.83","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00744-x"},{"key":"2026041022422426000_2025.01.22.633765v1.84","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2022.101073"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.01.22.633765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:13:22Z","timestamp":1782278002000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.01.22.633765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":84,"URL":"https:\/\/doi.org\/10.1101\/2025.01.22.633765","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1177\/08977151251383542","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2025,1,23]]},"subtype":"preprint"}}