{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:53:43Z","timestamp":1775886823957,"version":"3.50.1"},"posted":{"date-parts":[[2025,1,23]]},"group-title":"Developmental Biology","reference-count":142,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  The enteric nervous system (ENS) is formed from vagal neural crest cells (NCC), which generate most of the neurons and glia that regulate gastrointestinal function. Defects in the migration or differentiation of NCC in the gut can result in gastrointestinal disorders such as Hirschsprung disease (HSCR). Although mutations in many genes have been associated with the etiology of HSCR, a significant proportion of affected individuals have an undetermined genetic diagnosis. Therefore, it\u2019s important to identify new genes, modifiers and environmental factors that regulate ENS development and disease. Rdh10 catalyzes the first oxidative step in the metabolism of vitamin A to its active metabolite, RA, and is therefore a central regulator of vitamin A metabolism and retinoic acid (RA) synthesis during embryogenesis. We discovered that\n                  <jats:italic>retinol dehydrogenase 10<\/jats:italic>\n                  (\n                  <jats:italic>Rdh10<\/jats:italic>\n                  ) loss-of-function mouse embryos exhibit intestinal aganglionosis, characteristic of HSCR. Vagal NCC form and migrate in\n                  <jats:italic>Rdh10<\/jats:italic>\n                  mutant embryos but fail to invade the foregut.\n                  <jats:italic>Rdh10<\/jats:italic>\n                  is highly expressed in the mesenchyme surrounding the entrance to the foregut and is essential between E7.5-E9.5 for NCC invasion into the gut. Comparative RNA-sequencing revealed downregulation of the\n                  <jats:italic>Ret-Gdnf-Gfr\u03b11<\/jats:italic>\n                  gene signaling network in\n                  <jats:italic>Rdh10<\/jats:italic>\n                  mutants, which is critical for vagal NCC chemotaxis. Furthermore, the composition of the extracellular matrix through which NCC migrate is also altered, in part by increased collagen deposition. Collectively this restricts NCC entry into the gut, demonstrating that\n                  <jats:italic>Rdh10<\/jats:italic>\n                  -mediated vitamin A metabolism and RA signaling pleiotropically regulates the NCC microenvironment during ENS formation and in the pathogenesis of intestinal aganglionosis.\n                <\/jats:p>","DOI":"10.1101\/2025.01.23.634504","type":"posted-content","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T19:40:15Z","timestamp":1737661215000},"source":"Crossref","is-referenced-by-count":2,"title":["Rdh10-mediated Retinoic Acid Signaling Regulates the Neural Crest Cell Microenvironment During ENS Formation"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9507-4103","authenticated-orcid":false,"given":"Naomi E.","family":"Butler Tjaden","sequence":"first","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA"},{"name":"Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA"},{"name":"Department of Gastroenterology, Hepatology & Nutrition, Children\u2019s Hospital of Philadelphia, Philadelphia PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R.","family":"Shannon","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA"},{"name":"Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher W.","family":"Seidel","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Childers","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0304-9622","authenticated-orcid":false,"given":"Kazushi","family":"Aoto","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu City, Shizuoka, Japan 431-3192"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-8223","authenticated-orcid":false,"given":"Lisa L.","family":"Sandell","sequence":"additional","affiliation":[{"name":"University of Louisville, Department of Oral Immunology and Infectious Diseases, Louisville, KY, 40201, USA ORCID 0000-0002-1735-8223"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2774-3624","authenticated-orcid":false,"given":"Paul A.","family":"Trainor","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA"},{"name":"Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026041022301097000_2025.01.23.634504v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.01.003"},{"key":"2026041022301097000_2025.01.23.634504v1.2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02724"},{"key":"2026041022301097000_2025.01.23.634504v1.3","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.7601"},{"key":"2026041022301097000_2025.01.23.634504v1.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00759.x"},{"key":"2026041022301097000_2025.01.23.634504v1.5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.275"},{"key":"2026041022301097000_2025.01.23.634504v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)61346-7"},{"key":"2026041022301097000_2025.01.23.634504v1.7","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1948.00220250085005"},{"key":"2026041022301097000_2025.01.23.634504v1.8","unstructured":"Parisi, M.A. (2006) Hirschsprung Disease Overview. 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