{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:02:54Z","timestamp":1768568574965,"version":"3.49.0"},"posted":{"date-parts":[[2025,2,7]]},"group-title":"Neurology","reference-count":10,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,2,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>Patient-reported outcomes importantly reflect the lived experiences of persons with multiple sclerosis (MS); however, given the broad array of MS symptoms, comprehensive evaluation can be burdensome, especially with lengthy questionnaires. The MS Impact Scale queries twenty different physical difficulties (MSIS-20). In 1150 patients with MS, evaluation of internal consistency indicated redundancy in the MSIS-20 (Cronbach\u2019s alpha: 0.96), but optimal internal consistency (0.90) of a six-item short form (MSIS-SF; first six MSIS items). The MSIS-20 and MSIS-SF showed comparably strong associations with objective physical disability. The MSIS-SF provides a psychometrically robust, less burdensome, and time-efficient option for assessing patient-reported physical disturbance.<\/jats:p>","DOI":"10.1101\/2025.02.06.25321807","type":"posted-content","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T19:20:16Z","timestamp":1738956016000},"source":"Crossref","is-referenced-by-count":0,"title":["Validation of a Six-Item Multiple Sclerosis Impact Scale Short Form (MSIS-SF) for Efficient Assessment of Patient-Reported Physical Disturbance"],"prefix":"10.64898","author":[{"given":"James F.","family":"Sumowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2025020922050479000_2025.02.06.25321807v1.1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-3485.86879"},{"key":"2025020922050479000_2025.02.06.25321807v1.2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.5.962"},{"issue":"13","key":"2025020922050479000_2025.02.06.25321807v1.3","first-page":"e1395","article-title":"Detection of subtle gait disturbance and future fall risk in early multiple sclerosis","volume":"94","year":"2020","journal-title":"Neurology"},{"key":"2025020922050479000_2025.02.06.25321807v1.4","doi-asserted-by":"publisher","DOI":"10.1207\/S15327752JPA8001_18"},{"key":"2025020922050479000_2025.02.06.25321807v1.5","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.5.871"},{"key":"2025020922050479000_2025.02.06.25321807v1.6","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517690823"},{"key":"2025020922050479000_2025.02.06.25321807v1.7","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517690824"},{"key":"2025020922050479000_2025.02.06.25321807v1.8","doi-asserted-by":"publisher","DOI":"10.1177\/1352458509354552"},{"key":"2025020922050479000_2025.02.06.25321807v1.9","doi-asserted-by":"crossref","unstructured":"Sumowski JF , Sandry J. Multiple Sclerosis Cognitive Scale (MSCS): A brief psychometrically robust metric of patient-reported cognitive difficulty. Mult Scler. 2025 Feb 2;13524585241309804.","DOI":"10.1177\/13524585241309805"},{"key":"2025020922050479000_2025.02.06.25321807v1.10","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508096215"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.02.06.25321807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:27:29Z","timestamp":1768508849000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2025.02.06.25321807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,7]]},"references-count":10,"URL":"https:\/\/doi.org\/10.1101\/2025.02.06.25321807","relation":{},"subject":[],"published":{"date-parts":[[2025,2,7]]},"subtype":"preprint"}}