{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:42:23Z","timestamp":1768570943385,"version":"3.49.0"},"posted":{"date-parts":[[2025,2,13]]},"group-title":"Psychiatry and Clinical Psychology","reference-count":53,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,2,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The visual system is a significant site of pathology in psychosis spectrum disorders. However, there is limited research investigating human visual cortex (VC) subregions in this population. Using data from the Bipolar-Schizophrenia Network on Intermediate Phenotypes Consortium (BSNIP-1, BSNIP-2, PARDIP), this study examined structural measures in VC subregions in individuals with psychosis spectrum disorders.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>\n                    Cortical surface area and thickness in five VC subregions (hOc1, hOc2, hOc3v, hOc4v, MT) were quantified using FreeSurfer v7.1.0 and compared between individuals with psychosis (\n                    <jats:italic>n<\/jats:italic>\n                    =1211) and healthy controls (\n                    <jats:italic>n<\/jats:italic>\n                    =734). Regional specificity was examined by controlling for total surface area or mean cortical thickness. ComBat was used to harmonize scanner effects. Associations between VC measures and symptom severity, cognition, and childhood trauma scores were assessed.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    Individuals with psychosis demonstrated smaller surface area in hOc1, hOc2, and hOc3v, and lower cortical thickness in all five VC subregions compared to healthy controls. Thickness reductions in hOc1, hOc4v, and MT were regionally specific. hOc4v and MT were among the top three regions exhibiting the most robust cortical thickness deficits (\n                    <jats:italic>d<\/jats:italic>\n                    = \u22120.38 to \u22120.40) across all VC and Desikan-Killiany brain regions. Lower thickness in mid-level visual subregions were associated with greater positive symptoms, poorer cognition, and higher childhood trauma scores.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study demonstrates that the visual cortex is among the most profoundly affected brain regions in psychotic disorders. Different patterns of area and thickness changes across early and mid-level visual subregions, along with their varying associations with clinical measures, suggest distinct developmental and disease-related influences.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.02.12.25322031","type":"posted-content","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T14:45:17Z","timestamp":1739457917000},"source":"Crossref","is-referenced-by-count":0,"title":["Neuroanatomical Deficits in Visual Cortex Subregions of Individuals with Psychosis Spectrum Disorders linked to Symptoms, Cognition, and Childhood Trauma"],"prefix":"10.64898","author":[{"given":"Halide Bilge","family":"T\u00fcrk\u00f6zer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dung","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jothini","family":"Sritharan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Iska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena I.","family":"Ivleva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett A.","family":"Clementz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godfrey D.","family":"Pearlson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Keedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliot S.","family":"Gershon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A.","family":"Tamminga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matcheri S.","family":"Keshavan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Lizano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2025021504550425000_2025.02.12.25322031v1.1","doi-asserted-by":"crossref","unstructured":"Silverstein SM : Visual perception disturbances in schizophrenia: A unified model, in The Neuropsychopathology of Schizophrenia. 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