{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:08:43Z","timestamp":1768518523838,"version":"3.49.0"},"posted":{"date-parts":[[2025,2,18]]},"group-title":"Neuroscience","reference-count":80,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Collaborative Research in Computational Neuroscience Grant of the German Ministry of Education and Research","award":["01GQ2106"],"award-info":[{"award-number":["01GQ2106"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["425899996"],"award-info":[{"award-number":["425899996"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institutes of Health\u2019s National Institute on Aging","award":["5R01AG076198-02"],"award-info":[{"award-number":["5R01AG076198-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,8,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Path integration, the ability to track one\u2019s position using self-motion cues, is critically dependent on the grid cell network in the entorhinal cortex, a region vulnerable to early Alzheimer\u2019s disease pathology. In this study, we examined path integration performance in individuals with subjective cognitive decline (SCD), a group at increased risk for Alzheimer\u2019s disease, and healthy controls using an immersive virtual reality task. We developed a Bayesian computational model to decompose path integration errors into distinct components. SCD participants exhibited significantly higher path integration error, primarily driven by increased memory leak, while other modelling-derived error sources, such as velocity gain, sensory and reporting noise, remained comparable across groups. Our findings suggest that path integration deficits, specifically memory leak, may serve as an early marker of neurodegeneration in SCD and highlight the potential of self-motion-based navigation tasks for detecting pre-symptomatic Alzheimer\u2019s disease-related cognitive changes.<\/jats:p>\n                <jats:sec>\n                  <jats:title>Teaser<\/jats:title>\n                  <jats:p>Virtual reality, modelling, and plasma biomarkers reveal path integration deficits in pre-symptomatic Alzheimer\u2019s vs normal aging.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.02.17.638583","type":"posted-content","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T15:15:21Z","timestamp":1739891721000},"source":"Crossref","is-referenced-by-count":0,"title":["Path integration impairments reveal early cognitive changes in Subjective Cognitive Decline"],"prefix":"10.64898","author":[{"given":"Vladislava","family":"Segen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Rysul","family":"Kabir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Streck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Slavik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5865-4176","authenticated-orcid":false,"given":"Wenzel","family":"Glanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Butryn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehren","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Tiganj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Wolbers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2025090302100424000_2025.02.17.638583v2.1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10173"},{"key":"2025090302100424000_2025.02.17.638583v2.2","doi-asserted-by":"publisher","DOI":"10.3758\/s13423-015-0952-y"},{"key":"2025090302100424000_2025.02.17.638583v2.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0039-3"},{"key":"2025090302100424000_2025.02.17.638583v2.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"2025090302100424000_2025.02.17.638583v2.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2023.04.065"},{"key":"2025090302100424000_2025.02.17.638583v2.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.12.023"},{"key":"2025090302100424000_2025.02.17.638583v2.7","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1394"},{"key":"2025090302100424000_2025.02.17.638583v2.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.03.052"},{"key":"2025090302100424000_2025.02.17.638583v2.9","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz116"},{"key":"2025090302100424000_2025.02.17.638583v2.10","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-023-00976-6"},{"key":"2025090302100424000_2025.02.17.638583v2.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJ-Moa2212948"},{"key":"2025090302100424000_2025.02.17.638583v2.12","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12336"},{"key":"2025090302100424000_2025.02.17.638583v2.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"2025090302100424000_2025.02.17.638583v2.14","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1001\/jamaneurol.2017.2216","article-title":"Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global \u03b2-Amyloid Burden","volume":"74","year":"2017","journal-title":"JAMA Neurol"},{"key":"2025090302100424000_2025.02.17.638583v2.15","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-011-2696-x"},{"key":"2025090302100424000_2025.02.17.638583v2.16","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-006-0835-6"},{"key":"2025090302100424000_2025.02.17.638583v2.17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15805-9"},{"key":"2025090302100424000_2025.02.17.638583v2.18","unstructured":"J. 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