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Its potential applications are significant and broad, spanning clinical assessment of retinal disease, investigation of fundamental scientific questions, and rapid evaluation of experimental therapeutics for blinding retinal diseases. Progress in all these domains hinges on the development of robust methods for quantifying observed responses in relation to visible stimuli. In this work, we describe a novel optoretinographic imaging platform\u2013full-field swept-source optical coherence tomography with adaptive optics, measure cone responses in two healthy volunteers to a variety of stimulus patterns, and propose a simple model for predicting and quantifying responses to those stimuli.<\/jats:p>\n                <jats:sec>\n                  <jats:title>Teaser<\/jats:title>\n                  <jats:p>The function of human retinal neurons is quantified by the light they reflect, opening a new frontier in visual health<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.02.28.639986","type":"posted-content","created":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T02:15:14Z","timestamp":1740795314000},"source":"Crossref","is-referenced-by-count":0,"title":["Insight into human photoreceptor function: modeling optoretinographic responses to diverse stimuli"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1377-3585","authenticated-orcid":false,"given":"Denise","family":"Valente","sequence":"first","affiliation":[{"name":"Center for Human Ophthalmic Imaging Research (CHOIR), University of California, Davis Eye Center, 95817 Sacramento CA, USA"},{"name":"Fisica de Materiais, Escola Politecnica de Pernambuco, Universidade de Pernambuco, 50720-001 Recife PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3390-392X","authenticated-orcid":false,"given":"Kari V.","family":"Vienola","sequence":"additional","affiliation":[{"name":"Center for Human Ophthalmic Imaging Research (CHOIR), University of California, Davis Eye Center, 95817 Sacramento CA, USA"},{"name":"Institute of Biomedicine, University of Turku, 20520 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9574-156X","authenticated-orcid":false,"given":"Robert J.","family":"Zawadzki","sequence":"additional","affiliation":[{"name":"Center for Human Ophthalmic Imaging Research (CHOIR), University of California, Davis Eye Center, 95817 Sacramento CA, USA"},{"name":"EyePod small animal ocular imaging laboratory, Department of Cell Biology and Human Anatomy, University of California, 9816 Davis CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9545-1837","authenticated-orcid":false,"given":"Ravi S.","family":"Jonnal","sequence":"additional","affiliation":[{"name":"Center for Human Ophthalmic Imaging Research (CHOIR), University of California, Davis Eye Center, 95817 Sacramento CA, 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