{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:57:02Z","timestamp":1768568222349,"version":"3.49.0"},"posted":{"date-parts":[[2025,3,6]]},"group-title":"Respiratory Medicine","reference-count":26,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Sweat parameters such as volume and chloride concentration may offer invaluable clinical insights for people with CF (PwCF). Pilocarpine-induced sweat collection for chloridometry measurement is the gold-standard for sweat chloride, but this technique is cumbersome and not suitable for remote settings. We have previously reported the utility of a skin-interfaced microfluidic device (CF Patch) in conjunction with a smartphone image processing platform that enables real-time measurement of sweating rates and sodium chloride loss in laboratory and remote settings. Here we conducted clinical studies characterizing the accuracy of the CF Patch compared to pilocarpine-induced sweat measurements using chloridometry and tested the feasibility of exercise-induced sweat chloride measurements in PwCF. The CF Patch demonstrated strong correlations compared to sweat chloride measured by chloridometry across clinic and remote settings and detected greater day-to-day sweat chloride variability in PwCF on CFTR modulators than healthy volunteers. These findings demonstrate that the CF Patch is suitable as a remote management device capable of measuring chloride concentrations and offers the potential of monitoring the efficacy of CF medication regimens.<\/jats:p>","DOI":"10.1101\/2025.03.05.25323327","type":"posted-content","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T07:34:36Z","timestamp":1741332876000},"source":"Crossref","is-referenced-by-count":0,"title":["Remote exercise-induced sweat chloride measurements using a wearable microfluidic sticker in cystic fibrosis patients"],"prefix":"10.64898","author":[{"given":"Rachel S.","family":"Nelson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret G.","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zasu M.","family":"Klug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Calamari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Donayre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaddeus","family":"Cybulski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared","family":"Schooley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garett J.","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Corcos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald E.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica C.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da Som","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"John A.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roozbeh","family":"Ghaffari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AJ","family":"Aranyosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1534-5629","authenticated-orcid":false,"given":"Manu","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2025031102501528000_2025.03.05.25323327v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.05.005"},{"key":"2025031102501528000_2025.03.05.25323327v1.2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00551.2010"},{"key":"2025031102501528000_2025.03.05.25323327v1.3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jcf.2017.11.002","article-title":"The relationship between sweat chloride levels and mortality in cystic fibrosis varies by individual genotype","volume":"17","year":"2018","journal-title":"J Cyst Fibros"},{"key":"2025031102501528000_2025.03.05.25323327v1.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105185"},{"key":"2025031102501528000_2025.03.05.25323327v1.5","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1164\/rccm.201909-1845LE","article-title":"Females with Cystic Fibrosis Demonstrate a Differential Response Profile to Ivacaftor Compared with Males","volume":"201","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"2025031102501528000_2025.03.05.25323327v1.6","doi-asserted-by":"crossref","unstructured":"Ibrahim, H. et al. 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