{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:00:22Z","timestamp":1782280822185,"version":"3.54.5"},"posted":{"date-parts":[[2025,3,10]]},"group-title":"Neuroscience","reference-count":67,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Systemic viral infections with neurotropic potential pose significant global health challenges. The Zika virus (ZIKV) is known for its pronounced neurotropism, with recent infectious clusters raising renewed public health concerns. While research has predominantly focused on congenital populations, growing evidence suggests that the mature central nervous system (CNS) is also vulnerable. However, no study has examined the long-term impact of ZIKV infection on the adult human brain.<\/jats:p>\n                <jats:p>\n                  To address this gap, we studied a rare group of adult ZIKV patients presenting with both peripheral (Guillain-Barr\u00e9 Syndrome; GBS) and CNS-related neurological symptoms. We compared these patients at the chronic stage (5 to 12 months post-infection) to healthy controls and to patients with GBS of non-ZIKV etiology (total\n                  <jats:italic>N<\/jats:italic>\n                  =43). Structural and functional measures included cortical thickness, white matter hyperintensities, diffusion metrics, and resting-state functional connectivity.\n                <\/jats:p>\n                <jats:p>Despite the rarity of both patient populations, power analyses indicated that our sample size could detect large group differences\u2014effect sizes deemed reasonable given the severity of neurological symptoms in the ZIKV group. Nonetheless, our multimodal analyses yielded null results, with Bayesian statistics (where applicable) providing evidence for a lack of effects.<\/jats:p>\n                <jats:p>The null findings suggest that chronic ZIKV infection in adults is not associated with brain changes of large magnitude. Importantly, this study offers detailed clinical characterization of a heavily understudied group. In light of recent ZIKV outbreaks, this characterization underscores the need to monitor, study, and provide longitudinal care to adult survivors of severe ZIKV infections.<\/jats:p>","DOI":"10.1101\/2025.03.05.641727","type":"posted-content","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T15:20:17Z","timestamp":1741620017000},"source":"Crossref","is-referenced-by-count":0,"title":["A case-control neuroimaging investigation of chronic Zika virus-infected adults"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7849-0837","authenticated-orcid":false,"given":"Suhnyoung","family":"Jun","sequence":"first","affiliation":[{"name":"Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois"},{"name":"Department of Psychology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7424-875X","authenticated-orcid":false,"given":"Richard","family":"Bido-Medina","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairo","family":"Oviedo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Centro de Diagn\u00f3stico Medicina Avanzada y Telemedicina (CEDIMAT), Santo Domingo, Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidro","family":"Miches","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital Docente Salvador B. Gautier. Santo Domingo Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0933-1837","authenticated-orcid":false,"given":"Daniel","family":"Llano","sequence":"additional","affiliation":[{"name":"Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Tusen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Salvador B. 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