{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:06:28Z","timestamp":1768568788927,"version":"3.49.0"},"posted":{"date-parts":[[2025,3,14]]},"group-title":"Neurology","reference-count":75,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>INTRODUCTION<\/jats:title>\n                  <jats:p>Structural MRI often lacks diagnostic, prognostic, and monitoring value in Alzheimer\u2019s disease (AD), particularly in early disease stages. To improve its utility, we aimed to identify optimal MRI readouts for different use cases.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We included 363 older adults; healthy controls (HC) who were negative or positive for amyloid-beta (A\u03b2) and A\u03b2-positive patients with subjective cognitive decline (SCD), mild cognitive impairment, or dementia of the Alzheimer type. MRI and neuropsychological assessments were administered annually for up to three years.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Accelerated atrophy of distinct MTL subregions was evident already during preclinical AD. Symptomatic disease stages most notably differed in their hippocampal and parietal atrophy signatures. Associations of atrophy markers and cognitive inventories varied by intended use and disease stage.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>DISCUSSION<\/jats:title>\n                  <jats:p>With the appropriate readout, MRI can detect abnormal atrophy already during preclinical AD. To optimize performance, MRI readouts should be tailored to the targeted disease stage and intended use.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.03.13.25323904","type":"posted-content","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T19:45:31Z","timestamp":1741981531000},"source":"Crossref","is-referenced-by-count":0,"title":["Disease stage-specific atrophy markers in Alzheimer\u2019s disease"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5503-6308","authenticated-orcid":false,"given":"Hannah","family":"Baumeister","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7544-2311","authenticated-orcid":false,"given":"Helena M.","family":"Gellersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3862-8333","authenticated-orcid":false,"given":"Sarah E.","family":"Polk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Lattmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1779-3388","authenticated-orcid":false,"given":"Anika","family":"Wuestefeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7504-3943","authenticated-orcid":false,"given":"Laura E. M.","family":"Wisse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8626-7587","authenticated-orcid":false,"given":"Trevor","family":"Glenn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3868-284X","authenticated-orcid":false,"given":"Renat","family":"Yakupov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3812-023X","authenticated-orcid":false,"given":"Melina","family":"Stark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3309-6856","authenticated-orcid":false,"given":"Luca","family":"Kleineidam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8262-4356","authenticated-orcid":false,"given":"Sandra","family":"Roeske","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8174-9301","authenticated-orcid":false,"given":"Barbara","family":"Marcos Morgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5484-9710","authenticated-orcid":false,"given":"Hermann","family":"Esselmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3137-7516","authenticated-orcid":false,"given":"Frederic","family":"Brosseron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5770-0727","authenticated-orcid":false,"given":"Falk","family":"L\u00fcsebrink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-7273","authenticated-orcid":false,"given":"Matthis","family":"Synofzik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8237-4481","authenticated-orcid":false,"given":"Bj\u00f6rn H.","family":"Schott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias C.","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1773-1518","authenticated-orcid":false,"given":"Stefan","family":"Hetzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4005-3352","authenticated-orcid":false,"given":"Peter","family":"Dechent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6316-8773","authenticated-orcid":false,"given":"Klaus","family":"Scheffler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5231-1714","authenticated-orcid":false,"given":"Michael","family":"Ewers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0411-9204","authenticated-orcid":false,"given":"Julian","family":"Hellmann-Regen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6503-5894","authenticated-orcid":false,"given":"Ersin","family":"Ers\u00f6zl\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eike","family":"Spruth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gemenetzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0183-7510","authenticated-orcid":false,"given":"Klaus","family":"Fliessbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3023-9971","authenticated-orcid":false,"given":"Claudia","family":"Bartels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5189-134X","authenticated-orcid":false,"given":"Ayda","family":"Rostamzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5865-4176","authenticated-orcid":false,"given":"Wenzel","family":"Glanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2014-4098","authenticated-orcid":false,"given":"Enise I.","family":"Incesoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Janowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-6240","authenticated-orcid":false,"given":"Boris-Stephan","family":"Rauchmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3269-4452","authenticated-orcid":false,"given":"Ingo","family":"Kilimann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Sodenkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0966-0908","authenticated-orcid":false,"given":"Marie","family":"Coenjaerts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9854-2972","authenticated-orcid":false,"given":"Annika","family":"Spottke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7596-0979","authenticated-orcid":false,"given":"Josef","family":"Priller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9540-8700","authenticated-orcid":false,"given":"Anja","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-5330","authenticated-orcid":false,"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Buerger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1981-7435","authenticated-orcid":false,"given":"Robert","family":"Perneczky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3586-3194","authenticated-orcid":false,"given":"Stefan","family":"Teipel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3434-936X","authenticated-orcid":false,"given":"Christoph","family":"Laske","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2589-6440","authenticated-orcid":false,"given":"Michael","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6589-6416","authenticated-orcid":false,"given":"Gabriel","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1067-2102","authenticated-orcid":false,"given":"Frank","family":"Jessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emrah","family":"D\u00fczel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1558-1883","authenticated-orcid":false,"given":"David","family":"Berron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the DELCODE study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2025032002461888000_2025.03.13.25323904v1.1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"2025032002461888000_2025.03.13.25323904v1.2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae118"},{"key":"2025032002461888000_2025.03.13.25323904v1.3","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx243"},{"key":"2025032002461888000_2025.03.13.25323904v1.4","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00410-4"},{"key":"2025032002461888000_2025.03.13.25323904v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1142-7"},{"key":"2025032002461888000_2025.03.13.25323904v1.6","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.126"},{"key":"2025032002461888000_2025.03.13.25323904v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.09.016"},{"key":"2025032002461888000_2025.03.13.25323904v1.8","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab114"},{"key":"2025032002461888000_2025.03.13.25323904v1.9","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau5732"},{"key":"2025032002461888000_2025.03.13.25323904v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(95)02012-I"},{"key":"2025032002461888000_2025.03.13.25323904v1.11","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20940"},{"key":"2025032002461888000_2025.03.13.25323904v1.12","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"2025032002461888000_2025.03.13.25323904v1.13","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp059"},{"key":"2025032002461888000_2025.03.13.25323904v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.01.028"},{"key":"2025032002461888000_2025.03.13.25323904v1.15","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3338"},{"key":"2025032002461888000_2025.03.13.25323904v1.16","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01210-z"},{"key":"2025032002461888000_2025.03.13.25323904v1.17","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23602"},{"key":"2025032002461888000_2025.03.13.25323904v1.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.02.084"},{"key":"2025032002461888000_2025.03.13.25323904v1.19","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22627"},{"key":"2025032002461888000_2025.03.13.25323904v1.20","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24607"},{"key":"2025032002461888000_2025.03.13.25323904v1.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.09.011"},{"key":"2025032002461888000_2025.03.13.25323904v1.22","doi-asserted-by":"publisher","DOI":"10.3233\/jad-170945"},{"key":"2025032002461888000_2025.03.13.25323904v1.23","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12079"},{"key":"2025032002461888000_2025.03.13.25323904v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.06.009"},{"key":"2025032002461888000_2025.03.13.25323904v1.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.01.024"},{"key":"2025032002461888000_2025.03.13.25323904v1.26","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25151"},{"key":"2025032002461888000_2025.03.13.25323904v1.27","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.750154"},{"key":"2025032002461888000_2025.03.13.25323904v1.28","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-023-00779-6"},{"key":"2025032002461888000_2025.03.13.25323904v1.29","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0314-2"},{"key":"2025032002461888000_2025.03.13.25323904v1.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"2025032002461888000_2025.03.13.25323904v1.31","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-023-01751-2"},{"key":"2025032002461888000_2025.03.13.25323904v1.32","doi-asserted-by":"publisher","DOI":"10.1038\/srep26801"},{"key":"2025032002461888000_2025.03.13.25323904v1.33","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.8392"},{"issue":"3","key":"2025032002461888000_2025.03.13.25323904v1.34","first-page":"266","article-title":"The free and cued selective reminding test: evidence of psychometric adequacy","volume":"51","year":"2009","journal-title":"Psychology Science Quarterly"},{"key":"2025032002461888000_2025.03.13.25323904v1.35","unstructured":"Petermann F , Lepach A. Wechsler Memory Scale \u2013 Fourth Edition (WMS IV). Manual Zur Durchf\u00fchrung Und Auswertung. Deutsche \u00dcbersetzung Und Adaptation Der WMS IV von David Wechsler. Pearson; 2012."},{"key":"2025032002461888000_2025.03.13.25323904v1.36","doi-asserted-by":"crossref","unstructured":"Mohs RC , Knopman D , Petersen RC , et al. Development of Cognitive Instruments for Use in Clinical Trials of Antidementia Drugs: Additions to the Alzheimer\u2019s Disease Assessment Scale That Broaden Its Scope. Alzheimer Disease & Associated Disorders. 1997;11. https:\/\/journals.lww.com\/alzheimerjournal\/fulltext\/1997\/00112\/development_of_cognitive_instruments_for_use_in.3.aspx","DOI":"10.1097\/00002093-199700112-00003"},{"key":"2025032002461888000_2025.03.13.25323904v1.37","unstructured":"Smith A. Symbol Digit Modalities Test. Western Psychological Services; 1991."},{"key":"2025032002461888000_2025.03.13.25323904v1.38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054035"},{"key":"2025032002461888000_2025.03.13.25323904v1.39","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"2025032002461888000_2025.03.13.25323904v1.40","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/37.3.323"},{"key":"2025032002461888000_2025.03.13.25323904v1.41","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.12.2.233"},{"key":"2025032002461888000_2025.03.13.25323904v1.42","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"2025032002461888000_2025.03.13.25323904v1.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2017.10.004"},{"key":"2025032002461888000_2025.03.13.25323904v1.44","doi-asserted-by":"publisher","DOI":"10.1159\/000365637"},{"key":"2025032002461888000_2025.03.13.25323904v1.45","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1061"},{"key":"2025032002461888000_2025.03.13.25323904v1.46","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01571-z"},{"key":"2025032002461888000_2025.03.13.25323904v1.47","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25234"},{"key":"2025032002461888000_2025.03.13.25323904v1.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2022.102683"},{"key":"2025032002461888000_2025.03.13.25323904v1.49","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlz123"},{"key":"2025032002461888000_2025.03.13.25323904v1.50","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00264"},{"key":"2025032002461888000_2025.03.13.25323904v1.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.08.059"},{"key":"2025032002461888000_2025.03.13.25323904v1.52","doi-asserted-by":"publisher","DOI":"10.1101\/2024.10.25.620237"},{"key":"2025032002461888000_2025.03.13.25323904v1.53","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing. Published online 2022. https:\/\/www.R-project.org\/"},{"key":"2025032002461888000_2025.03.13.25323904v1.54","doi-asserted-by":"publisher","DOI":"10.1207\/s15327906mbr3203_1"},{"key":"2025032002461888000_2025.03.13.25323904v1.55","doi-asserted-by":"publisher","DOI":"10.1007\/s11336-014-9435-8"},{"key":"2025032002461888000_2025.03.13.25323904v1.56","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.70089"},{"key":"2025032002461888000_2025.03.13.25323904v1.57","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad411"},{"key":"2025032002461888000_2025.03.13.25323904v1.58","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2015.00054"},{"key":"2025032002461888000_2025.03.13.25323904v1.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2023.103374"},{"key":"2025032002461888000_2025.03.13.25323904v1.60","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-020-00395-3"},{"key":"2025032002461888000_2025.03.13.25323904v1.61","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(19)30368-0"},{"key":"2025032002461888000_2025.03.13.25323904v1.62","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12336"},{"key":"2025032002461888000_2025.03.13.25323904v1.63","doi-asserted-by":"publisher","DOI":"10.3233\/jad-161252"},{"key":"2025032002461888000_2025.03.13.25323904v1.64","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.2216"},{"key":"2025032002461888000_2025.03.13.25323904v1.65","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172913.88973.0d"},{"key":"2025032002461888000_2025.03.13.25323904v1.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.10.009"},{"key":"2025032002461888000_2025.03.13.25323904v1.67","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002593"},{"key":"2025032002461888000_2025.03.13.25323904v1.68","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2018-0096"},{"key":"2025032002461888000_2025.03.13.25323904v1.69","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt222"},{"key":"2025032002461888000_2025.03.13.25323904v1.70","doi-asserted-by":"publisher","DOI":"10.1017\/s1355617720000934"},{"key":"2025032002461888000_2025.03.13.25323904v1.71","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0342-8"},{"key":"2025032002461888000_2025.03.13.25323904v1.72","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.30.051606.094328"},{"key":"2025032002461888000_2025.03.13.25323904v1.73","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20985"},{"key":"2025032002461888000_2025.03.13.25323904v1.74","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70052"},{"key":"2025032002461888000_2025.03.13.25323904v1.75","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009058"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.03.13.25323904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:30:53Z","timestamp":1768509053000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2025.03.13.25323904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,14]]},"references-count":75,"URL":"https:\/\/doi.org\/10.1101\/2025.03.13.25323904","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1002\/alz.70482","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2025,3,14]]},"subtype":"preprint"}}