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This scoping review evaluates the use of unstructured data from electronic health records (EHRs) to identify ADEs in children. We searched six databases, including MEDLINE, Embase and IEEE Xplore, in September 2024. From 984 records, only nine studies met our inclusion criteria, indicating a significant gap in research towards identify ADEs in children. We found that unstructured data in EHRs can indeed be of value and enhance pediatric pharmacovigilance, although its use has been so far very limited. Traditional Natural Language Processing (NLP) methods have been employed to extract ADEs, but the approaches utilized face challenges in generalizability and context interpretation. These challenges could be addressed with recent advances in transformer-based models and large language models (LLMs), unlocking the use of EHR data at scale for pediatric pharmacovigilance.<\/jats:p>","DOI":"10.1101\/2025.03.20.25324320","type":"posted-content","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T01:25:36Z","timestamp":1742693136000},"source":"Crossref","is-referenced-by-count":3,"title":["Leveraging Unstructured Data in Electronic Health Records to Detect Adverse Events from Pediatric Drug Use - A Scoping Review"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8987-5211","authenticated-orcid":false,"given":"Su","family":"Golder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7709-3813","authenticated-orcid":false,"given":"Karen","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5903-1483","authenticated-orcid":false,"given":"Guillermo","family":"Lopez-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2700-2597","authenticated-orcid":false,"given":"Nicholas","family":"Tatonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6416-9556","authenticated-orcid":false,"given":"Graciela","family":"Gonzalez-Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025032405000464000_2025.03.20.25324320v1.1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2018.1491547"},{"key":"2025032405000464000_2025.03.20.25324320v1.2","doi-asserted-by":"crossref","first-page":"100188","DOI":"10.1016\/j.eclinm.2019.10.001","article-title":"Reported adverse drug reactions in women and men: Aggregated evidence from globally collected individual case reports during half a century","volume":"17","year":"2019","journal-title":"EClinicalMedicine"},{"issue":"Suppl 1","key":"2025032405000464000_2025.03.20.25324320v1.3","first-page":"S41","article-title":"Adherence to therapy and adverse drug reactions: is there a link?","volume":"13","year":"2014","journal-title":"Expert Opin Drug Saf"},{"key":"2025032405000464000_2025.03.20.25324320v1.4","unstructured":"Organization WH . 2002. 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