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In\n                  <jats:italic>P. falciparum<\/jats:italic>\n                  Rh5, with PfCyRPA, PfRipr, PfCSS, and PfPTRAMP, forms the essential PCRCR complex which binds basigin on the erythrocyte surface. Rh5 is restricted to\n                  <jats:italic>P. falciparum<\/jats:italic>\n                  and its close relatives; however, PTRAMP, CSS and Ripr orthologs are present across the\n                  <jats:italic>Plasmodium<\/jats:italic>\n                  genus. We investigated PTRAMP, CSS and Ripr orthologs from three species to elucidate common features of the complex. Like\n                  <jats:italic>P. falciparum,<\/jats:italic>\n                  PTRAMP and CSS form a disulfide-linked heterodimer in both\n                  <jats:italic>P. vivax<\/jats:italic>\n                  and\n                  <jats:italic>P. knowlesi<\/jats:italic>\n                  with all three species forming a complex (PCR) with Ripr by binding its C-terminal region. Cross-reactive antibodies targeting the PCR complex differentially inhibit merozoite invasion. Cryo-EM visualization of the\n                  <jats:italic>P. knowlesi<\/jats:italic>\n                  PCR complex confirmed predicted models and revealed a core invasion scaffold in\n                  <jats:italic>Plasmodium<\/jats:italic>\n                  spp. with implications for vaccines targeting multiple species of malaria-causing parasites.\n                <\/jats:p>","DOI":"10.1101\/2025.03.25.644866","type":"posted-content","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T04:25:57Z","timestamp":1742963157000},"source":"Crossref","is-referenced-by-count":5,"title":["PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of\n                  <i>Plasmodium<\/i>\n                  species into erythrocytes"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3161-1849","authenticated-orcid":false,"given":"Benjamin A.","family":"Seager","sequence":"first","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia"},{"name":"University of Melbourne, Melbourne 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3196-2651","authenticated-orcid":false,"given":"Pailene S.","family":"Lim","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia"},{"name":"University of Melbourne, Melbourne 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2111-0466","authenticated-orcid":false,"given":"Keng Heng","family":"Lai","sequence":"additional","affiliation":[{"name":"Research Centre for Infectious Diseases, School of Biological Sciences, The University of Adelaide, Australia 5005"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1578-455X","authenticated-orcid":false,"given":"Lionel Brice","family":"Feufack-Donfack","sequence":"additional","affiliation":[{"name":"Malaria Research Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7694-8867","authenticated-orcid":false,"given":"Sheena","family":"Dass","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T.H. 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