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Magnetic Resonance Elastography (MRE) provides a unique perspective by mapping brain tissue stiffness and damping ratio, observables that correlate with age and disease. Using a self-supervised contrastive regression framework, we demonstrate that MRE surpasses conventional structural magnetic resonance imaging (MRI) in sensitivity. Specifically, stiffness captures Alzheimer\u2019s disease (AD), while damping ratio detects subtle changes associated with mild cognitive impairment (MCI). Our regional analysis identifies deep brain structures, particularly the caudate and thalamus, as key biomarkers of aging. The greater age sensitivity of MRE translates to superior differentiation of AD and MCI from healthy individuals, pinpointing regions where significant biomechanical alterations occur, notably the thalamus in AD and hippocampus in MCI. Furthermore, our results reveal biomechanical alterations in cognitively healthy individuals whose aging profiles closely resemble patients with MCI and AD. These findings highlight MRE\u2019s potential as a biomarker for early neurodegenerative changes, aiding dementia risk detection and early intervention.<\/jats:p>","DOI":"10.1101\/2025.03.25.645330","type":"posted-content","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T14:45:15Z","timestamp":1743000315000},"source":"Crossref","is-referenced-by-count":0,"title":["Enhancing Brain Age Prediction and Neurodegeneration Detection with Contrastive Learning on Regional Biomechanical Properties"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2619-9395","authenticated-orcid":false,"given":"J.","family":"Tr\u00e4uble","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6296-7442","authenticated-orcid":false,"given":"L.V.","family":"Hiscox","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7760-131X","authenticated-orcid":false,"given":"C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Delaware, Newark, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8878-0325","authenticated-orcid":false,"given":"A.","family":"Aviles-Rivero","sequence":"additional","affiliation":[{"name":"Yau Mathematical Sciences Center, Tsinghua University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0099-6306","authenticated-orcid":false,"given":"C.B.","family":"Sch\u00f6nlieb","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1843-2202","authenticated-orcid":false,"given":"G.S. 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