{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:03:30Z","timestamp":1782281010388,"version":"3.54.5"},"posted":{"date-parts":[[2025,4,1]]},"group-title":"Cell Biology","reference-count":50,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>ABSTRACT\/SUMMARY<\/jats:title>\n                <jats:p>\n                  Reproductive aging is an increasing health concern affecting family planning and overall well-being. While extensively studied in females, the mechanisms driving male reproductive aging remain largely unexamined. Here we found that mammalian Sirtuin 7 (SIRT7) sustains spermatogenesis in an age-dependent manner through the control of histone 3 lysine 36 acetylation (H3K36ac). SIRT7 deficiency in mice resulted in increased levels of H3K36ac in spermatogonia and spermatocytes. In a germ cell line, SIRT7 deficiency disrupted nucleosome stability and increased vulnerability to genotoxic stress. Importantly, undifferentiated spermatogonia, which are required for continuous sperm production, decreased prematurely in\n                  <jats:italic>\n                    Sirt7\n                    <jats:sup>-\/-<\/jats:sup>\n                  <\/jats:italic>\n                  mice and showed genome damage accumulation. These changes were concurrent with age-dependent defects in homologous chromosome synapsis and partial meiotic arrest. Taken together, our results indicate that SIRT7 connects H3K36ac epigenetic regulation to long-term genome stability in male germ cells, ensuring steady-state spermatogenesis during the lengthy male reproductive lifespan.\n                <\/jats:p>","DOI":"10.1101\/2025.03.31.645534","type":"posted-content","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:20:11Z","timestamp":1743553211000},"source":"Crossref","is-referenced-by-count":0,"title":["SIRT7 links H3K36ac epigenetic regulation with genome maintenance in the aging mouse testis"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2110-6990","authenticated-orcid":false,"given":"Anna","family":"Guitart-Solanes","sequence":"first","affiliation":[{"name":"Chromatin Biology Laboratory, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, Spain"},{"name":"Doctoral program in Biomedicine, Universitat de Barcelona 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