{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:50:10Z","timestamp":1787010610895,"version":"build-2736575974"},"posted":{"date-parts":[[2025,4,6]]},"group-title":"Cancer Biology","reference-count":90,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T00:00:00Z","timestamp":1743897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,4,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                <jats:p>\n                  High-fat diet (HFD) intake has been linked to an increased risk of pancreatic ductal adenocarcinoma (PDAC), a lethal and therapy-resistant cancer. However, whether and how specific dietary fats drive cancer development remains unresolved. Leveraging an oncogenic\n                  <jats:italic>Kras<\/jats:italic>\n                  -driven mouse model that closely mimics human PDAC progression, we screened a dozen isocaloric HFDs differing solely in fat source and representing the diversity of human fat consumption. Unexpectedly, diets rich in oleic acid \u2013 a monounsaturated fatty acid (MUFA) typically associated with good health \u2013 markedly enhanced tumorigenesis. Conversely, diets high in polyunsaturated fatty acids (PUFAs) suppressed tumor progression. Relative dietary fatty acid saturation levels (PUFA\/MUFA) governed pancreatic membrane phospholipid composition, lipid peroxidation, and ferroptosis sensitivity in mice, concordant with circulating PUFA\/MUFA levels being linked to altered PDAC risk in humans. These findings directly implicate dietary unsaturated fatty acids in controlling ferroptosis susceptibility and tumorigenesis, supporting potential \u201cprecision nutrition\u201d strategies for PDAC prevention.\n                <\/jats:p>","DOI":"10.1101\/2025.04.04.645324","type":"posted-content","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T19:25:11Z","timestamp":1743967511000},"source":"Crossref","is-referenced-by-count":6,"title":["Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas"],"prefix":"10.64898","author":[{"given":"Christian Felipe","family":"Ruiz","sequence":"first","affiliation":[{"name":"Department of Genetics, Yale University School of Medicine; New Haven, CT 06520, USA"},{"name":"Yale Cancer Biology Institute, Yale University; West Haven, CT 06516, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Ge","sequence":"additional","affiliation":[{"name":"Yale Cancer Biology Institute, Yale University; 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