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In adult\n                  <jats:italic>Drosophila<\/jats:italic>\n                  , gut tumors secrete the PDGF\/VEGF-like factor Pvf1, which activates the TORC1-Hnf4 pathway in hepatocyte-like oenocytes. This drives production of very long-chain fatty acids and wax esters essential for tracheal growth around the tumor. Blocking Hnf4 or the elongase mElo in oenocytes strongly suppresses tracheogenesis, tumor progression, and cachexia-like organ wasting, while extending host lifespan. The same pathway also controls tracheal development in healthy flies. Lipoprotein receptor\n                  <jats:italic>LpR2<\/jats:italic>\n                  depletion in oenocytes rescues the observed tumor induced tracheal tracheal remodeling. This tumor-host interaction is conserved: VEGF-A induces lipid metabolism genes in human hepatocytes, and lung tumor-bearing mice show elevated hepatic\n                  <jats:italic>Hnf4<\/jats:italic>\n                  and\n                  <jats:italic>Elovl7<\/jats:italic>\n                  . The study reveals a non-autonomous role of the TORC1-Hnf4 axis in lipid-mediated tumor progression and identifies potential therapeutic targets for cancer-associated metabolic dysfunction.\n                <\/jats:p>","DOI":"10.1101\/2025.04.04.647255","type":"posted-content","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T17:25:11Z","timestamp":1743873911000},"source":"Crossref","is-referenced-by-count":2,"title":["Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in\n                  <i>Drosophila<\/i>"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1866-8407","authenticated-orcid":false,"given":"K.","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, 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