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Many studies focus on cell renewal through regeneration, while fewer studies explore mechanisms that promote cell longevity despite cell death stimuli. Here, we reveal that the adult\n                  <jats:italic>Drosophila<\/jats:italic>\n                  hindgut ileum is an excellent model to study tissue maintenance by long-lived cells. Hindgut ileal enterocytes resist the damaging detergent SDS and upstream caspase signaling by\n                  <jats:italic>head-involution-defective (hid).<\/jats:italic>\n                  This\n                  <jats:italic>hid-<\/jats:italic>\n                  induced death insensitivity arises early in adulthood and associates with numerous transcriptional changes. We interrogated 82 of these transcriptional changes in a candidate screen for enhancers of\n                  <jats:italic>hid-<\/jats:italic>\n                  induced death in the ileum. Top among our screen hits is an immunoglobulin family cell adhesion gene,\n                  <jats:italic>CG15312. CG15312<\/jats:italic>\n                  maintains the adhesion protein FasIII on cell membranes. In\n                  <jats:italic>hid-<\/jats:italic>\n                  expressing ileal cells,\n                  <jats:italic>CG15312<\/jats:italic>\n                  loss causes cell death and pyknotic nuclear clustering. We name this conserved gene\n                  <jats:bold>\n                    <jats:italic>lo<\/jats:italic>\n                  <\/jats:bold>\n                  <jats:italic>\n                    w\n                    <jats:bold>o<\/jats:bold>\n                    n-membrane\n                    <jats:bold>f<\/jats:bold>\n                    <jats:underline>a<\/jats:underline>\n                    s and enhancer of\n                    <jats:underline>h<\/jats:underline>\n                    id\n                  <\/jats:italic>\n                  (\n                  <jats:italic>loofah<\/jats:italic>\n                  ). Our findings reveal a new mechanism linking cell adhesion and cell death resistance in a long-lived cell type. Our work establishes a new model to study tissue preservation.\n                <\/jats:p>","DOI":"10.1101\/2025.04.04.647274","type":"posted-content","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T17:35:11Z","timestamp":1743874511000},"source":"Crossref","is-referenced-by-count":0,"title":["Loofah, a newly characterized adhesion protein, suppresses cell death in long-lived\n                  <i>Drosophila<\/i>\n                  hindgut enterocytes"],"prefix":"10.64898","author":[{"given":"Jessica K.","family":"Sawyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth A.","family":"Montague","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Goddard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archan","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo B.","family":"Belato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0436-179X","authenticated-orcid":false,"given":"Donald T.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2025040808551142000_2025.04.04.647274v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2016.10.011"},{"key":"2025040808551142000_2025.04.04.647274v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.10.016"},{"key":"2025040808551142000_2025.04.04.647274v1.3","first-page":"20883","article-title":"\u2019Epithelial transport of drugs in cell culture. 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