{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:50:45Z","timestamp":1789501845389,"version":"build-2803163510"},"posted":{"date-parts":[[2025,4,21]]},"group-title":"Neuroscience","reference-count":96,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"crossref","award":["Z01-DC000002 from NIDCD"],"award-info":[{"award-number":["Z01-DC000002 from NIDCD"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"crossref","award":["R01 DC016807 from NIDCD"],"award-info":[{"award-number":["R01 DC016807 from NIDCD"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,12,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>Vestibular hair cells (HCs) convert gravitational and head motion cues into neural signals through mechanotransduction, mediated by the hair bundle\u2014a mechanically integrated organelle composed of stereocilia and a kinocilium. The kinocilium, a specialized form of primary cilium, remains incompletely defined in structure, molecular composition, and function. To elucidate its characteristics, we conducted single-cell RNA sequencing of adult vestibular and cochlear HCs, uncovering a selective enrichment of primary and motile cilia\u2013associated genes in vestibular HCs, particularly those related to the axonemal repeat complex. This enrichment of orthologous axonemal-related genes was conserved in zebrafish and human vestibular HCs, indicating a shared molecular architecture. Immunostaining validated the expression of key motile cilia markers in vestibular kinocilia. Moreover, live imaging of bullfrog and mouse HCs from crista ampullaris revealed spontaneous kinociliary motion. Together, these findings define the kinocilium as a unique organelle with molecular features of primary and motile cilia and suggest its previously unknown role as an active, force-generating element within the hair bundle.<\/jats:p>","DOI":"10.1101\/2025.04.16.647417","type":"posted-content","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:22:22Z","timestamp":1745410942000},"source":"Crossref","is-referenced-by-count":2,"title":["The Dual Molecular Identity of Vestibular Kinocilia: Bridging Structural and Functional Traits of Primary and Motile Cilia"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9527-5207","authenticated-orcid":false,"given":"Zhenhang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178 Department of Otorhinolaryngology \u0336 Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China, Department of Otorhinolaryngology 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