{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:09:37Z","timestamp":1792786177779,"version":"4.5.0"},"posted":{"date-parts":[[2025,4,24]]},"group-title":"Neuroscience","reference-count":39,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Council","award":["MC-A658-5TY30"],"award-info":[{"award-number":["MC-A658-5TY30"]}]},{"name":"Israel Science Foundation","award":["1939\/23"],"award-info":[{"award-number":["1939\/23"]}],"id":[{"id":"https:\/\/ror.org\/04sazxf24","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Russian Science Foundation","award":["25-76-30006"],"award-info":[{"award-number":["25-76-30006"]}],"id":[{"id":"https:\/\/ror.org\/03y2gwe85","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  The nematode\n                  <jats:italic>C. elegans<\/jats:italic>\n                  does not have eyes but can respond to aversive UV and blue light stimulation and even distinguish colours. The gustatory receptor homolog LITE-1 was identified in forward genetic screens for worms that failed to respond to blue light stimulation. When LITE-1 is expressed in body-wall muscles, it causes contraction in response to blue light suggesting that LITE-1 is both necessary and sufficient for blue light response. Here we show that in addition to light avoidance, LITE-1 is also required for worms\u2019 avoidance of high concentrations of diacetyl, an odorant that is attractive at low concentrations. Like blue light, diacetyl causes muscle contraction in transgenic worms engineered to express LITE-1 in body-wall muscles. These data are consistent with a direct chemoreceptor function for LITE-1 which would make it a multimodal sensor of aversive stimuli.\n                <\/jats:p>","DOI":"10.1101\/2025.04.20.649642","type":"posted-content","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T13:15:10Z","timestamp":1745500510000},"source":"Crossref","is-referenced-by-count":0,"title":["The\n                  <i>C. elegans<\/i>\n                  gustatory receptor homolog LITE-1 is a chemoreceptor required for diacetyl avoidance"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9267-455X","authenticated-orcid":false,"given":"Alan","family":"Koh","sequence":"first","affiliation":[{"name":"MRC Laboratory of Medical Sciences, London, UK"},{"name":"Institute of Clinical Sciences, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2257-9180","authenticated-orcid":false,"given":"Eduard","family":"Bokman","sequence":"additional","affiliation":[{"name":"Department of Genetics, Silberman Institute of Life Science, Edmond J. 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