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Imprinted genes, including Prader-Willi syndrome\n                  <jats:italic>Snord116<\/jats:italic>\n                  noncoding RNAs, are implicated in the regulation of sleep and circadian rhythms through poorly understood mechanisms. Utilizing mouse models of\n                  <jats:italic>Snord116<\/jats:italic>\n                  deficiency and overexpression, we performed an integrated, sex-stratified analysis of free running behaviors, indirect calorimetry, and cortical transcriptomes following entrainment to a 22 hour light:dark T-cycle. We observed significant interactions of sex, entrainment, and\n                  <jats:italic>Snord116<\/jats:italic>\n                  genotype in period length at baseline and after-effects of post-entrainment.\n                  <jats:italic>Snord116<\/jats:italic>\n                  deletion\u2019s effect on respiratory exchange ratio was light sensitive, with sex and entrainment effects dominant under total darkness.\n                  <jats:italic>Snord116<\/jats:italic>\n                  genotype impacted both rhythmic and non-rhythmic cortical gene networks that integrated sex, light, and entrainment effects with genotype-phenotype correlations. A co-expressed gene network enriched for imprinted,\n                  <jats:italic>Snord116<\/jats:italic>\n                  -target, and\n                  <jats:italic>Xist<\/jats:italic>\n                  -proximal long noncoding RNAs was identified as a light-sensitive regulatory hub of sexual dimorphic responses to a dynamic environment.\n                <\/jats:p>","DOI":"10.1101\/2025.05.01.651733","type":"posted-content","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:45:11Z","timestamp":1746665111000},"source":"Crossref","is-referenced-by-count":1,"title":["Light and sex modify\n                  <i>Snord116<\/i>\n                  genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment"],"prefix":"10.64898","author":[{"given":"Aron Judd P.","family":"Mendiola","sequence":"first","affiliation":[{"name":"UC Davis School of Medicine Department of Medical Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Rutkowsky","sequence":"additional","affiliation":[{"name":"UC Davis Mouse Metabolic Phenotyping Center"},{"name":"UC Davis School of Veterinary Medicine Department of Molecular Biosciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Neier","sequence":"additional","affiliation":[{"name":"UC Davis School of Medicine Department of Medical Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Hakam","sequence":"additional","affiliation":[{"name":"UC Davis School of Medicine Department of Medical Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Sharifi","sequence":"additional","affiliation":[{"name":"UC Davis School of Medicine Department of Medical Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Callum","family":"Donnelly","sequence":"additional","affiliation":[{"name":"UC Davis School of Veterinary Medicine Department of Molecular Biosciences"},{"name":"Cornell University, College of Veterinary Medicine, Department of Clinical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Torres","sequence":"additional","affiliation":[{"name":"UC Davis School of Medicine Department of Medical Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cielo","family":"Hernandez","sequence":"additional","affiliation":[{"name":"UC Davis School of Medicine Department of Medical Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag H.","family":"Yasui","sequence":"additional","affiliation":[{"name":"UC Davis School of Medicine Department of Medical Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon J.","family":"Ramsey","sequence":"additional","affiliation":[{"name":"UC Davis School of Veterinary Medicine Department of Molecular Biosciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine M.","family":"LaSalle","sequence":"additional","affiliation":[{"name":"UC Davis School of Medicine Department of Medical Microbiology and Immunology"},{"name":"UC Davis Genome Center"},{"name":"UC Davis Perinatal Origins of Disparities Center"},{"name":"UC Davis MIND Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026041120493747000_2025.05.01.651733v1.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abp9556"},{"key":"2026041120493747000_2025.05.01.651733v1.2","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/hep.32363","article-title":"Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to 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