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This study compares the transcriptome of these two obstetric syndromes. By integrating available microarray and single-cell placenta\/decidua transcriptomic datasets, we demonstrated that early onset preeclampsia genes are inversely expressed in placenta accreta, with the most marked differences noted in cell types of decidua, endothelial, and extravillous trophoblasts. Our findings highlight the key functions of trophoblast cell migration and invasion, decidua cell signaling, hypoxia pathways, and global growth factor and collagen contributions to these pregnancy disorders. This research provides new insights into the mechanisms of placentation and unifies these clinical siloes of disease by focusing on the fundamental biology of placental development at the maternal-fetal interface.<\/jats:p>","DOI":"10.1101\/2025.05.09.653201","type":"posted-content","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T21:10:20Z","timestamp":1747257020000},"source":"Crossref","is-referenced-by-count":0,"title":["Transcriptomic comparison of early onset preeclampsia and placenta accreta identifies inverse trophoblast and decidua functions at the maternal-fetal interface"],"prefix":"10.64898","author":[{"given":"Ophelia","family":"Yin","sequence":"first","affiliation":[{"name":"Division of Maternal-Fetal Medicine and Reproductive Genetics, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Almonte-Loya","sequence":"additional","affiliation":[{"name":"Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA"},{"name":"Biomedical Informatics Program, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Appierdo","sequence":"additional","affiliation":[{"name":"Program in Cellular and Molecular Biology, Department of Biology, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar D.","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomiko T.","family":"Oskotsky","sequence":"additional","affiliation":[{"name":"Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA"},{"name":"UCSF Division of Clinical Informatics and Digital Transformation, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine and Reproductive Genetics, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda C.","family":"Giudice","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalda","family":"Afshar","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA"},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Sirota","sequence":"additional","affiliation":[{"name":"Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA"},{"name":"Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026041121510212000_2025.05.09.653201v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70227-X"},{"key":"2026041121510212000_2025.05.09.653201v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00413-2"},{"key":"2026041121510212000_2025.05.09.653201v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05869-0"},{"key":"2026041121510212000_2025.05.09.653201v1.4","doi-asserted-by":"crossref","unstructured":"ACOG Practice Bulletin. 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