{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:54:43Z","timestamp":1768571683156,"version":"3.49.0"},"posted":{"date-parts":[[2025,5,16]]},"group-title":"Nutrition","reference-count":102,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,5,16]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Gestational diabetes mellitus (GDM) is associated with increased placental weight and the presence of placental malperfusion lesions, likely related to high blood glucose. The relationship between high glucose without overt GDM, and placental characteristics is not well understood.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To examine the relationships between glucose challenge test (GCT) concentrations, GDM, and placental characteristics associated with GDM.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>\n                    We conducted a secondary analysis of medical record data from singleton placentas sent to pathology at Northwestern Memorial Hospital (2011-2022; n=11,585). Data included maternal demographic variables, GCT concentrations, GDM diagnosis, placental weight, and vascular malperfusion lesions (accelerated villous maturation, increased syncytial knots, delayed villous maturation, and increased perivillous fibrin deposition). We classified GCT &lt;140 mg\/dL as pass and \u2265140 mg\/dL as fail. We categorized glucose groups into\n                    <jats:italic>pass GCT\/no GDM<\/jats:italic>\n                    ,\n                    <jats:italic>fail GCT\/no GDM<\/jats:italic>\n                    , and\n                    <jats:italic>GDM<\/jats:italic>\n                    . We used linear and Poisson regression models to examine the association between GCT concentrations or groups with placental outcomes, adjusting for maternal age, race and ethnicity, parity, gestational age at delivery, and infant sex.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    Of placentas sent to pathology, 5% were from pregnancies with GDM and 17% from those who failed the GCT but did not get diagnosed with GDM. Compared to the\n                    <jats:italic>pass GCT\/no GDM<\/jats:italic>\n                    group, the adjusted mean placental weight was heavier by 13.6 grams [95% CI: 8.8, 18.3] in the\n                    <jats:italic>fail GCT\/no GDM<\/jats:italic>\n                    and 22.0 grams [13.8, 30.2] in the\n                    <jats:italic>GDM<\/jats:italic>\n                    group. Patients diagnosed with GDM had a 36% [2%, 81%] increased adjusted risk of delayed villous maturation compared to the\n                    <jats:italic>pass GCT\/no GDM<\/jats:italic>\n                    . The risk of the other lesions was not statistically significantly different between groups.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>GDM and high glucose concentrations without GDM were associated with heavier placentas; patients with GDM had a higher risk of delayed villous maturation.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.05.14.25327646","type":"posted-content","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T15:15:19Z","timestamp":1747408519000},"source":"Crossref","is-referenced-by-count":0,"title":["The relationship between maternal glucose concentrations, gestational diabetes mellitus, placental weight, and placental vascular malperfusion lesions: a retrospective study of a U.S. pregnancy cohort"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7335-414X","authenticated-orcid":false,"given":"Amrita","family":"Arcot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery A.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5661-7785","authenticated-orcid":false,"given":"Alison D.","family":"Gernand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2025052007150639000_2025.05.14.25327646v1.1","unstructured":"Centers for Disease Control and Prevention, U.S. Department of Health and Human Services. 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