{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:28:06Z","timestamp":1785403686627,"version":"3.56.0"},"posted":{"date-parts":[[2025,5,21]]},"group-title":"Neuroscience","reference-count":132,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["946666"],"award-info":[{"award-number":["946666"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R03 AG081865"],"award-info":[{"award-number":["R03 AG081865"]}],"id":[{"id":"https:\/\/ror.org\/049v75w11","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,5,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>\n                    The renin-angiotensin-aldosterone system (RAAS) has been shown to be dysregulated in dementia, with elevated levels of angiotensin-converting enzyme (ACE), angiotensin (Ang) II, and Ang II type 1 receptors (AT\n                    <jats:sub>1<\/jats:sub>\n                    Rs). Cerebral amyloid angiopathy (CAA), a common cerebrovascular disease, currently has no treatment or cure available. We aimed to determine if a mouse model with CAA (Tg-SwDI) also exhibits elevated levels of AT\n                    <jats:sub>1<\/jats:sub>\n                    Rs and whether RAAS-targeting drugs (telmisartan and lisinopril) mitigate these effects.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>\n                    Tg-SwDI mice were treated with sub-depressor doses of either telmisartan or lisinopril from 3-8 months of age, with blood pressure being monitored 2 and 4 months after the start of treatment. Postmortem, receptor autoradiography was performed to determine levels of AT\n                    <jats:sub>1<\/jats:sub>\n                    R in 13 brain regions in untreated and treated Tg-SwDI mice compared to wild-type controls (C57Bl\/6J).\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>No statistically significant differences among groups were observed in any of the 13 regions analyzed. However, trends with medium to large effect sizes were observed.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>\n                    CAA did not significantly dysregulate AT\n                    <jats:sub>1<\/jats:sub>\n                    R levels in the brains of Tg-SwDI mice compared to wild-type mice. Drug treatment caused no significant brain AT\n                    <jats:sub>1<\/jats:sub>\n                    R alterations. Further studies are required to determine if the trends observed are pathophysiological and pharmacologically significant.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.05.16.654535","type":"posted-content","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T17:25:21Z","timestamp":1747848321000},"source":"Crossref","is-referenced-by-count":0,"title":["Chronic Treatment of a Mouse Model of Cerebral Amyloid Angiopathy and Brain AT\n                  <sub>1<\/sub>\n                  Receptor Expression"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6662-0970","authenticated-orcid":false,"given":"Natalia","family":"Motzko Noto","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5110-9183","authenticated-orcid":false,"given":"Lisa S.","family":"Robison","sequence":"additional","affiliation":[{"name":"Department of Psychology and Behavioral Neuroscience, College of Psychology, Nova Southeastern University, Fort Lauderdale, FL 33328, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6434-2136","authenticated-orcid":false,"given":"Robert C.","family":"Speth","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA"},{"name":"Department of Pharmacology and Physiology, School of Medicine, Georgetown University, Washington, DC 20057"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026041122484567000_2025.05.16.654535v1.1","unstructured":"Fountain JH and Lappin SL. 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