{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:47:43Z","timestamp":1768567663221,"version":"3.49.0"},"posted":{"date-parts":[[2025,5,22]]},"group-title":"Neurology","reference-count":27,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,5,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Investigating the relationships between socioemotional functioning and Alzheimer\u2019s Disease (AD) pathology can contribute to screening and early detection of AD. This study explored the associations between socioemotional functioning and cerebrospinal fluid (CSF) AD biomarkers in older adults.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used baseline data from the Advancing Reliable Measurement in Alzheimer\u2019s Disease and Cognitive Aging (ARMADA) study. ARMADA is a multisite study with independent protocols for CSF assays at each site. The available sample size with comparable CSF assays had 31 participants with normal cognition (NC) and 28 with amnestic mild cognitive impairment (aMCI) or early-stage AD dementia. CSF-derived AD biomarkers included were: phosphorylated-tau 181 (p-Tau181), total tau (t-Tau), A\u03b242, A\u03b242\/40 ratio, and p-Tau181\/A\u03b242 ratio. Socioemotional functioning (negative affect, psychological wellbeing, and social satisfaction) was measured with the self-reported NIH Toolbox Emotion Battery (NIHTB-EB). We ran linear regressions by cognitive subgroups (NC and aMCI\/early-stage AD).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among participants with NC, lower social satisfaction was associated with higher p-Tau181 and t-Tau; higher t-Tau was additionally associated with more negative affect. None of the CSF AD biomarkers were associated with the NIHTB-EB outcomes among participants with aMCI or early-stage AD.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>These findings suggest that socioemotional functioning may be associated with tau pathology. Markers for amyloid were not related to socioemotional functioning regardless of disease stages. Future studies with larger, more diverse samples and harmonized CSF assay protocols are needed to further examine the role of early socioemotional change in early detection and prevention of dementia.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.05.19.25327619","type":"posted-content","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T12:20:18Z","timestamp":1747916418000},"source":"Crossref","is-referenced-by-count":0,"title":["The NIH Toolbox Emotion Battery and Cerebrospinal Fluid Biomarkers in Alzheimer\u2019s Disease: Findings from the Multisite ARMADA Study"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4201-5270","authenticated-orcid":false,"given":"Kexin","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3892-9742","authenticated-orcid":false,"given":"Jennifer R.","family":"Gatchel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3522-3779","authenticated-orcid":false,"given":"Emily H.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6096-5304","authenticated-orcid":false,"given":"Ihab","family":"Hajjar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9487-415X","authenticated-orcid":false,"given":"Steven E.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9096-2355","authenticated-orcid":false,"given":"Gad A.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7290-8307","authenticated-orcid":false,"given":"Hiroko H.","family":"Dodge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2025052408550705000_2025.05.19.25327619v1.1","doi-asserted-by":"publisher","DOI":"10.2147\/PROM.S151658"},{"key":"2025052408550705000_2025.05.19.25327619v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2016.04.004"},{"key":"2025052408550705000_2025.05.19.25327619v1.3","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191078"},{"key":"2025052408550705000_2025.05.19.25327619v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2019.05.005"},{"key":"2025052408550705000_2025.05.19.25327619v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2019.03.023"},{"key":"2025052408550705000_2025.05.19.25327619v1.6","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12103"},{"key":"2025052408550705000_2025.05.19.25327619v1.7","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0345-x"},{"key":"2025052408550705000_2025.05.19.25327619v1.8","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17040442"},{"key":"2025052408550705000_2025.05.19.25327619v1.9","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.2657"},{"key":"2025052408550705000_2025.05.19.25327619v1.10","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01314-6"},{"key":"2025052408550705000_2025.05.19.25327619v1.11","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170001"},{"key":"2025052408550705000_2025.05.19.25327619v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01249-0"},{"key":"2025052408550705000_2025.05.19.25327619v1.13","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00822-7"},{"key":"2025052408550705000_2025.05.19.25327619v1.14","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610217002368"},{"key":"2025052408550705000_2025.05.19.25327619v1.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"2025052408550705000_2025.05.19.25327619v1.16","unstructured":"NIH Toolbox Scoring and Interpretation Guide. 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