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Pulmonary microenvironment during\n                  <jats:italic>Mtb<\/jats:italic>\n                  infection is largely governed by lung resident macrophages, initiating innate and subsequent adaptive immune responses. We investigated the role of PKC\u03b4 in macrophages using a macrophage-specific PKC\u03b4 knockout mice model (LysM\n                  <jats:sup>cre<\/jats:sup>\n                  PKC\u03b4\n                  <jats:sup>flox\/flox<\/jats:sup>\n                  ). PKC\u03b4 deficiency in macrophages triggers an early lymphocytic immune response, increases neutrophil recruitment, and reduces inflammatory macrophages in the lungs, leading to higher\n                  <jats:italic>Mtb<\/jats:italic>\n                  burden and exacerbated pathology. Experimental and omics analysis further revealed that dysregulation of antimicrobial effector functions is detrimental to macrophage\u2019s ability to restrict bacterial growth\n                  <jats:italic>in vitro<\/jats:italic>\n                  . Importantly this defect was mitigated by exogenous GM-CSF supplementation and\/or overexpressing PKC\u03b4 in macrophages. Thus, PKC\u03b4 plays a crucial role in immune modulation during\n                  <jats:italic>Mtb<\/jats:italic>\n                  infection with GM-CSF amongst several downstream pathways through which PKC\u03b4 exerts its regulatory effects.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>Teaser<\/jats:title>\n                  <jats:p>\n                    PKC\u03b4 is crucial for immune modulation during\n                    <jats:italic>Mtb<\/jats:italic>\n                    infection revealing macrophages as a potential axis of signaling.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.05.19.653976","type":"posted-content","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:40:16Z","timestamp":1748047216000},"source":"Crossref","is-referenced-by-count":0,"title":["Protein Kinase C \u03b4: a critical hub regulating macrophage immunomodulatory functions during\n                  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