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Here, an\n                  <jats:italic>LYPD1<\/jats:italic>\n                  reporter mouse model on a C57Bl\/6J background with specifically labeled group 1C, low-SR ANFs was used to examine whether\n                  <jats:italic>LYPD1<\/jats:italic>\n                  positive ANF synapses are more vulnerable to noise exposure. Six-week-old mice were exposed to an 8-16 kHz octave band noise presented at 100 dBA for 2 hours. One week later, cochlear tissue was harvested to quantify ANF synapses and compare the percentage of\n                  <jats:italic>LYPD1<\/jats:italic>\n                  positive ANF synapses in noise-exposed and unexposed animals. Auditory brainstem response measurements were performed to assess hearing function after noise exposure. The number of all ANF synapses and the percentage of\n                  <jats:italic>LYPD1-<\/jats:italic>\n                  positive ANF synapses were reduced following noise exposure, concurrent with increased ABR thresholds and decreased ABR wave 1 amplitudes. The reduction in the percentage of\n                  <jats:italic>LYPD1-<\/jats:italic>\n                  positive ANF synapses specifically indicates greater vulnerability of\n                  <jats:italic>LYPD1<\/jats:italic>\n                  positive ANF synapses to noise exposure compared to other ANFs in C57Bl\/6J mice.\n                <\/jats:p>","DOI":"10.1101\/2025.05.19.654865","type":"posted-content","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T18:50:11Z","timestamp":1747853411000},"source":"Crossref","is-referenced-by-count":2,"title":["Increased vulnerability to noise exposure of low spontaneous rate type 1C spiral ganglion neuron synapses with inner hair cells (Pre-Print)"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6485-588X","authenticated-orcid":false,"given":"Daniel O. 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