{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:15:24Z","timestamp":1787505324427,"version":"build-2736575974"},"posted":{"date-parts":[[2025,5,21]]},"group-title":"Public and Global Health","reference-count":0,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,5,21]]},"abstract":"<jats:p>Physical activity and mobility are critical for healthy aging and predict diverse health outcomes. While wrist-worn accelerometers are widely used to monitor physical activity, estimating gait metrics from wrist data remains challenging. We extend ElderNet, a self-supervised deep-learning model previously validated for walking-bout detection, to estimate gait metrics from wrist accelerometry. Validation involved 819 older adults (Rush-Memory-and-Aging-Project) and 85 individuals with gait impairments (Mobilise-D), from six medical centers. In Mobilise-D, ElderNet achieved an absolute error of 8.82 cm\/s and an intra-class correlation of 0.87 for gait speed, outperforming state-of-the-art methods (p &lt; 0.001) and models using a lower-back sensor. ElderNet outperformed (percentage error; p &lt; 0.01) competing approaches in estimating cadence and stride length, and better (p &lt; 0.01) classified mobility disability (AUC = 0.80) than conventional gait or physical activity metrics. These results render ElderNet a scalable tool for gait assessment using wrist-worn devices in aging and clinical populations.<\/jats:p>","DOI":"10.1101\/2025.05.21.25328061","type":"posted-content","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:15:15Z","timestamp":1747872915000},"source":"Crossref","is-referenced-by-count":2,"title":["Continuous Assessment of Daily-Living Gait Using Self-Supervised Learning of Wrist-Worn Accelerometer Data"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4214-0699","authenticated-orcid":false,"given":"Yonatan E.","family":"Brand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6426-2742","authenticated-orcid":false,"given":"Aron S.","family":"Buchman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4921-6104","authenticated-orcid":false,"given":"Felix","family":"Kluge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Palmerini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cereatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Maetzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrix","family":"Vereijken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J.","family":"Yarnall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Rochester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Del Din","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Hausdorff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Or","family":"Perlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.05.21.25328061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:36:40Z","timestamp":1768509400000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2025.05.21.25328061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1101\/2025.05.21.25328061","relation":{},"subject":[],"published":{"date-parts":[[2025,5,21]]},"subtype":"preprint"}}