{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:18:17Z","timestamp":1785410297063,"version":"3.56.0"},"posted":{"date-parts":[[2025,5,30]]},"group-title":"Neuroscience","reference-count":47,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["EY031690"],"award-info":[{"award-number":["EY031690"]}],"id":[{"id":"https:\/\/ror.org\/03wkg3b53","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,5,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  The clustered protocadherins (cPcdhs) are a family of \u223c60 homophilic cell adhesion molecules expressed across three gene clusters (\n                  <jats:italic>Pcdha, Pcdhb<\/jats:italic>\n                  , and\n                  <jats:italic>Pcdhg<\/jats:italic>\n                  ) with a variety of essential roles in the developing nervous system. Some of these roles rely on specific isoforms, while others are more consistent with a model of isoform redundancy or a requirement for diversity. The \u03b3-Pcdhs (expressed from the\n                  <jats:italic>Pcdhg<\/jats:italic>\n                  gene cluster) are particularly important for neuronal self-avoidance in starburst amacrine cells in the mouse retina. Here, we used mouse mutants to test two of the C-type isoforms \u2013 \u03b3C4 and \u03b3C5 \u2013 and found that neither was required for normal self-avoidance. Conversely, when we analyzed a mutant with only \u03b3C4 intact, we found significant failures in self-avoidance that could not be completely rescued by overexpression of this isoform from a transgene. We have recently found that this isoform is essential for normal neuronal survival during development, and our new findings here support the hypothesis that \u03b3C4 is specialized for the survival function at the expense of a significant role in self-avoidance.\n                <\/jats:p>","DOI":"10.1101\/2025.05.29.656828","type":"posted-content","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T03:30:12Z","timestamp":1748662212000},"source":"Crossref","is-referenced-by-count":0,"title":["Reduced neuronal self-avoidance in mouse starburst amacrine cells with only one\n                  <i>Pcdhg<\/i>\n                  isoform"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5224-5913","authenticated-orcid":false,"given":"Cathy M.","family":"McLeod","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3054-7827","authenticated-orcid":false,"given":"Seoyoung","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7538-019X","authenticated-orcid":false,"given":"Muhammad Nazmul","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-2585","authenticated-orcid":false,"given":"Andrew M.","family":"Garrett","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI"},{"name":"Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026041200223400000_2025.05.29.656828v1.1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150414"},{"key":"2026041200223400000_2025.05.29.656828v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.10.009"},{"key":"2026041200223400000_2025.05.29.656828v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80789-8"},{"key":"2026041200223400000_2025.05.29.656828v1.4","doi-asserted-by":"publisher","DOI":"10.1101\/gr.167301"},{"key":"2026041200223400000_2025.05.29.656828v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.07.012"},{"key":"2026041200223400000_2025.05.29.656828v1.6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004526107"},{"key":"2026041200223400000_2025.05.29.656828v1.7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1713449114"},{"key":"2026041200223400000_2025.05.29.656828v1.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.04.004"},{"key":"2026041200223400000_2025.05.29.656828v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2017.07.023"},{"key":"2026041200223400000_2025.05.29.656828v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.09.026"},{"key":"2026041200223400000_2025.05.29.656828v1.11","doi-asserted-by":"crossref","unstructured":"Brasch, J. , et al., Visualization of clustered protocadherin neuronal self-recognition complexes. 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