{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:28:09Z","timestamp":1768523289355,"version":"3.49.0"},"posted":{"date-parts":[[2025,5,30]]},"group-title":"Bioengineering","reference-count":108,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH\/NIDCR"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,5,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Vital pulp treatments (VPT) aim to conservatively manage deep caries and\/or damage to preserve the vitality and function of the pulp. This minimally invasive approach is still debated when performing direct pulp capping (DPC), a treatment in which a protective biocompatible material is directly placed over the dental pulp, due to microbial risks inherent with pulp exposure and difficulties in sealing the exposure to protect the pulp from subsequent bacterial ingress. Several limitations associated with Mineral Trioxide Aggregate (MTA) such as long setting time and discoloration have promoted the development of next-generation MTA derivatives with enhanced physical, chemical, and biological properties. As these materials are relatively new, existing studies are limited in scope, lacking a comprehensive assessment of both reparative dentin formation and the sealing ability, which are critical parameters for determining long-term clinical success. These assessments require preclinical models, and while the mouse model offers the opportunity to explore the molecular mechanisms guiding reparative dentinogenesis, the materials and techniques optimized for human dentition present technical challenges in mice due to their small size.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>We aimed to optimize a DPC technique to use in mice by comparing the tissue responses and the sealing ability of three calcium silicate capping agents: Bioceramic putty (BC), Biodentine (BD), and Theracal-LC (TLC) to a control material known to seal well but cause desiccation that would lead to tissue damage; Cavit-G (CG).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Material and methods<\/jats:title>\n                  <jats:p>DPC was performed on the maxillary first molar of C57BL\/6 female mice. Reparative dentin was assessed with micro-computed tomography (micro-CT) and histological assessment of dentin bridge formation at 21 days. The sealing ability of the capping materials was evaluated using micro-CT.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>All three calcium silicate materials showed good biocompatibility and the ability to form a dentin bridge. Micro-CT quantifications of material voids demonstrated superior seals with bioceramic putty and Theracal-LC groups as compared to Biodentine.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Ready-to-use, premixed capping agents exhibit better sealing ability in mice, while promoting dentin bridge formation to protect the dental pulp.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.05.29.656939","type":"posted-content","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T21:30:20Z","timestamp":1748640620000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparative Evaluation of Three Calcium Silicate-Based Materials for Direct Pulp Capping: An\n                  <i>In Vivo<\/i>\n                  Study in Mice"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8761-7158","authenticated-orcid":false,"given":"Fatma","family":"Fenesha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1848-0335","authenticated-orcid":false,"given":"Aonjittra","family":"Phanrungsuwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dane","family":"Kanniard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3444-0576","authenticated-orcid":false,"given":"Brian L.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5081-8060","authenticated-orcid":false,"given":"Anibal","family":"Diogenes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3384-5109","authenticated-orcid":false,"given":"Sarah B.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"issue":"1","key":"2025060223250799000_2025.05.29.656939v1.1","first-page":"3","article-title":"The global increase in dental caries. 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