{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:06:53Z","timestamp":1778810813350,"version":"3.51.4"},"posted":{"date-parts":[[2025,6,4]]},"group-title":"Psychiatry and Clinical Psychology","reference-count":68,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,6,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>INTRODUCTION<\/jats:title>\n                  <jats:p>Diffusion-weighted imaging derived mean diffusivity (MD) correlates with Alzheimer\u2019s disease biomarkers, yet its neuropathological correlates remain unclear.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Diffusion-weighted imaging, postmortem neuropathology, and cognitive performance data were obtained from the National Alzheimer\u2019s Coordinating Center (N=97), Alzheimer\u2019s Disease Neuroimaging Initiative (N=21), and Arizona Study of Aging and Neurodegenerative Disorders (N=15). We examined MD associations with neuropathology, cognitive decline, and expression profiles of AD-implicated genes.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Results revealed two latent variables\u2014one linked to amyloid\/tau, the other to vascular pathology\u2014explaining 70% and 16% of MD-pathology covariance, respectively. Higher MD correlated with worse cognitive performance, both cross-sectionally and up to 14 years prior to death. MD was regionally associated with Thal phase, neuritic plaque density, Braak stage (temporal\/limbic), and infarcts (thalamus), and reflected gene expression patterns related to AD.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>DISCUSSION<\/jats:title>\n                  <jats:p>In vivo MD captures distinct AD-related pathologies across brain regions and relates to cognitive trajectories and gene expression.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.05.30.25328630","type":"posted-content","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T17:45:22Z","timestamp":1749059122000},"source":"Crossref","is-referenced-by-count":2,"title":["Gray matter microstructure from in-vivo diffusion MRI reflects post-mortem neuropathology severity and clinical progression of Alzheimer\u2019s disease"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1164-6950","authenticated-orcid":false,"given":"Zaki","family":"Alasmar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cilia","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roqaie","family":"Moqadam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9527-2011","authenticated-orcid":false,"given":"Geidy E","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas 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