{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:34:33Z","timestamp":1790908473747,"version":"4.1.0"},"posted":{"date-parts":[[2025,6,9]]},"group-title":"Neuroscience","reference-count":47,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002112","name":"A.P. 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This self-monitoring capability also enables speech neuroprosthesis users to recognize mistakes in decoded output upon receiving visual or auditory feedback. However, it remains unknown whether neural activity related to error detection is present in the speech motor cortex. In this study, we demonstrate the existence of neural error signals in speech motor cortex firing rates during intracortical brain-to-text speech neuroprosthesis use. This activity could be decoded to enable the neuroprosthesis to identify its own errors with up to 86% accuracy. Additionally, we observed distinct neural patterns associated with specific types of mistakes, such as phonemic or semantic differences between the person\u2019s intended and displayed words. These findings reveal how feedback errors are represented within the speech motor cortex, and suggest strategies for leveraging these additional cognitive signals to improve neuroprostheses.<\/jats:p>","DOI":"10.1101\/2025.06.07.658426","type":"posted-content","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T04:55:30Z","timestamp":1749444930000},"source":"Crossref","is-referenced-by-count":6,"title":["Error encoding in human speech motor cortex"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2066-8561","authenticated-orcid":false,"given":"Xianda","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of California, Davis, Davis, CA, USA"},{"name":"Computer Science Graduate Group, University of California, Davis, Davis, CA, 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