{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T11:05:29Z","timestamp":1775991929601,"version":"3.50.1"},"posted":{"date-parts":[[2025,6,15]]},"group-title":"Neuroscience","reference-count":69,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:00:00Z","timestamp":1749945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministry of Health of the Czech Republic","doi-asserted-by":"crossref","award":["NU21-08-00373"],"award-info":[{"award-number":["NU21-08-00373"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Union\u2019s Horizon Europe program","award":["101087124"],"award-info":[{"award-number":["101087124"]}]},{"DOI":"10.13039\/501100011659","name":"Faculty of Medicine, Masaryk University","doi-asserted-by":"crossref","award":["MUNI\/A\/1738\/2024"],"award-info":[{"award-number":["MUNI\/A\/1738\/2024"]}],"id":[{"id":"10.13039\/501100011659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100019624","name":"University Hospital Hradec Kr\u00e1lov\u00e9","doi-asserted-by":"crossref","award":["00179906"],"award-info":[{"award-number":["00179906"]}],"id":[{"id":"10.13039\/100019624","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,6,15]]},"abstract":"<jats:title>Structured Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>INTRODUCTION<\/jats:title>\n                  <jats:p>The Pathogen Infection Hypothesis proposes that \u03b2-Amyloid (A\u03b2) functions as an antimicrobial peptide, with pathogen-induced aggregation potentially contributing to Alzheimer\u2019s disease (AD) pathology.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>\n                    We used human iPSC-derived 2D neurons and 3D cerebral organoids from wild-type and familial AD (\n                    <jats:italic>PSEN1\/2<\/jats:italic>\n                    mutant) lines to model acute infections with HSV-1 and TBEV and A\u03b2 aggregation. Transcriptomic and proteomic analyses were conducted to assess molecular responses.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>\n                    HSV-1, but not TBEV, induced robust A\u03b2 clustering, which was, however, dependent on extracellular amyloid peptides. Transcriptomic profiling revealed widespread HSV-1-induced changes, including activation of neurodegeneration-related pathways. Proteomic profiling confirmed enrichment of neurodegeneration- and senescence-associated secretome signatures.\n                    <jats:italic>PSEN1\/2<\/jats:italic>\n                    mutations did not alter the acute infection response. Reanalysis of independent datasets confirmed our findings and revealed a limited protective effect of acyclovir.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>DISCUSSION<\/jats:title>\n                  <jats:p>Results directly support the Pathogen Infection Hypothesis and suggest that preventing viral infections via vaccinations may represent a feasible approach to reducing AD risk.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.06.11.659008","type":"posted-content","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T23:05:19Z","timestamp":1750028719000},"source":"Crossref","is-referenced-by-count":0,"title":["Viral Infection Induces Alzheimer\u2019s Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3403-7085","authenticated-orcid":false,"given":"Hana","family":"Hribkova","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7629-678X","authenticated-orcid":false,"given":"Veronika","family":"Pospisilova","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3094-0402","authenticated-orcid":false,"given":"Katerina","family":"Amruz Cerna","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5145-895X","authenticated-orcid":false,"given":"Tereza","family":"Vanova","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic"},{"name":"International Clinical Research Center, St. Anne\u2019s University Hospital Brno, Pekarska 53, Brno 602 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Haviernik","sequence":"additional","affiliation":[{"name":"Veterinary Research Institute, Hudcova 296\/70, Brno 621 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5589-1061","authenticated-orcid":false,"given":"Jiri","family":"Sedmik","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2188-332X","authenticated-orcid":false,"given":"Ondrej","family":"Bernatik","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1824-468X","authenticated-orcid":false,"given":"Jaroslav","family":"Olha","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7957-0214","authenticated-orcid":false,"given":"Jan","family":"Raska","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic"},{"name":"International Clinical Research Center, St. Anne\u2019s University Hospital Brno, Pekarska 53, Brno 602 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7644-6207","authenticated-orcid":false,"given":"Sona","family":"Cesnarikova","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Satkova","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9215-4926","authenticated-orcid":false,"given":"Klara","family":"Plesingrova","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Strakova","sequence":"additional","affiliation":[{"name":"Veterinary Research Institute, Hudcova 296\/70, Brno 621 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Fortova","sequence":"additional","affiliation":[{"name":"Veterinary Research Institute, Hudcova 296\/70, Brno 621 00, Czech Republic"},{"name":"Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic"},{"name":"Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branisovska 1160\/31, Ceske Budejovice 370 05, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Gresova","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Genomics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manolis","family":"Maragkakis","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Genomics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Sadibolova","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Kupcik","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Fabrik","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Vajrychova","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Sheardova","sequence":"additional","affiliation":[{"name":"International Clinical Research Center, St. Anne\u2019s University Hospital Brno, Pekarska 53, Brno 602 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ruzek","sequence":"additional","affiliation":[{"name":"Veterinary Research Institute, Hudcova 296\/70, Brno 621 00, Czech Republic"},{"name":"Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic"},{"name":"Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branisovska 1160\/31, Ceske Budejovice 370 05, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9538-6668","authenticated-orcid":false,"given":"Dasa","family":"Bohaciakova","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic"},{"name":"International Clinical Research Center, St. Anne\u2019s University Hospital Brno, Pekarska 53, Brno 602 00, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026041203343581000_2025.06.11.659008v1.1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"2026041203343581000_2025.06.11.659008v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.056"},{"key":"2026041203343581000_2025.06.11.659008v1.3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031039"},{"key":"2026041203343581000_2025.06.11.659008v1.4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503689102"},{"key":"2026041203343581000_2025.06.11.659008v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.05.006"},{"key":"2026041203343581000_2025.06.11.659008v1.6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008596"},{"key":"2026041203343581000_2025.06.11.659008v1.7","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-021-01520-7"},{"key":"2026041203343581000_2025.06.11.659008v1.8","doi-asserted-by":"publisher","DOI":"10.4161\/viru.1.5.12983"},{"key":"2026041203343581000_2025.06.11.659008v1.9","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.2.126"},{"key":"2026041203343581000_2025.06.11.659008v1.10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306220110"},{"key":"2026041203343581000_2025.06.11.659008v1.11","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00324"},{"key":"2026041203343581000_2025.06.11.659008v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.09.077"},{"key":"2026041203343581000_2025.06.11.659008v1.13","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711670403"},{"key":"2026041203343581000_2025.06.11.659008v1.14","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08800-x"},{"key":"2026041203343581000_2025.06.11.659008v1.15","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220361"},{"key":"2026041203343581000_2025.06.11.659008v1.16","unstructured":"Differences in Long COVID severity by duration of illness, symptom evolution, and vaccination: a longitudinal cohort study from the INSPIRE group - The Lancet Regional Health \u2013 Americas n.d. https:\/\/www.thelancet.com\/journals\/lanam\/article\/PIIS2667-193X(25)00036-5\/fulltext (accessed February, 2025)."},{"key":"2026041203343581000_2025.06.11.659008v1.17","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230746"},{"key":"2026041203343581000_2025.06.11.659008v1.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100845"},{"key":"2026041203343581000_2025.06.11.659008v1.19","doi-asserted-by":"publisher","DOI":"10.1038\/nature12517"},{"key":"2026041203343581000_2025.06.11.659008v1.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.03.004"},{"key":"2026041203343581000_2025.06.11.659008v1.21","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-021-10254-3"},{"key":"2026041203343581000_2025.06.11.659008v1.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2021.102379"},{"key":"2026041203343581000_2025.06.11.659008v1.23","doi-asserted-by":"publisher","DOI":"10.1002\/cpcb.51"},{"key":"2026041203343581000_2025.06.11.659008v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113310"},{"key":"2026041203343581000_2025.06.11.659008v1.25","doi-asserted-by":"publisher","DOI":"10.3390\/v14020354"},{"key":"2026041203343581000_2025.06.11.659008v1.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104968"},{"key":"2026041203343581000_2025.06.11.659008v1.27","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10101532"},{"key":"2026041203343581000_2025.06.11.659008v1.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2021.100270"},{"key":"2026041203343581000_2025.06.11.659008v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101563"},{"key":"2026041203343581000_2025.06.11.659008v1.30","unstructured":"R: a language and environment for statistical computing \u2013 ScienceOpen n.d. https:\/\/www.scienceopen.com\/book?vid=b164ea90-95d2-43bf-9710-99753c479112 (accessed February, 2025)."},{"key":"2026041203343581000_2025.06.11.659008v1.31","unstructured":"org.Hs.eg.db. Bioconductor n.d. http:\/\/bioconductor.org\/packages\/org.Hs.eg.db\/ (accessed February, 2025)."},{"key":"2026041203343581000_2025.06.11.659008v1.32","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"2026041203343581000_2025.06.11.659008v1.33","doi-asserted-by":"crossref","unstructured":"SortMeRNA: fast and accurate filtering of ribosomal RNAs in metatranscriptomic data | Bioinformatics | Oxford Academic n.d. https:\/\/academic.oup.com\/bioinformatics\/article\/28\/24\/3211\/246053?login=false (accessed February, 2025).","DOI":"10.1093\/bioinformatics\/bts611"},{"key":"2026041203343581000_2025.06.11.659008v1.34","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"2026041203343581000_2025.06.11.659008v1.35","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"2026041203343581000_2025.06.11.659008v1.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141"},{"key":"2026041203343581000_2025.06.11.659008v1.37","doi-asserted-by":"crossref","unstructured":"ggplot2: Elegant Graphics for Data Analysis | Journal of the Royal Statistical Society Series A: Statistics in Society | Oxford Academic n.d. https:\/\/academic.oup.com\/jrsssa\/article\/174\/1\/245\/7077675?login=false (accessed February, 2025).","DOI":"10.1111\/j.1467-985X.2010.00676_9.x"},{"key":"2026041203343581000_2025.06.11.659008v1.38","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx364"},{"key":"2026041203343581000_2025.06.11.659008v1.39","unstructured":"Yu G. Introduction | Biomedical Knowledge Mining using GOSemSim and clusterProfiler. https:\/\/yulab-smu.top\/biomedical-knowledge-mining-book\/"},{"key":"2026041203343581000_2025.06.11.659008v1.40","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1245904"},{"key":"2026041203343581000_2025.06.11.659008v1.41","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-021-01012-9"},{"key":"2026041203343581000_2025.06.11.659008v1.42","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-023-01405-y"},{"key":"2026041203343581000_2025.06.11.659008v1.43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49133-z"},{"key":"2026041203343581000_2025.06.11.659008v1.44","doi-asserted-by":"publisher","DOI":"10.32614\/CRAN.package.msigdbr"},{"key":"2026041203343581000_2025.06.11.659008v1.45","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.207"},{"key":"2026041203343581000_2025.06.11.659008v1.46","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1106"},{"key":"2026041203343581000_2025.06.11.659008v1.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.06.030"},{"key":"2026041203343581000_2025.06.11.659008v1.48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009505"},{"key":"2026041203343581000_2025.06.11.659008v1.49","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac4296"},{"key":"2026041203343581000_2025.06.11.659008v1.50","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-024-01198-8"},{"key":"2026041203343581000_2025.06.11.659008v1.51","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay8828"},{"key":"2026041203343581000_2025.06.11.659008v1.52","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02219-20"},{"key":"2026041203343581000_2025.06.11.659008v1.53","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00111-19"},{"key":"2026041203343581000_2025.06.11.659008v1.54","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23115981"},{"key":"2026041203343581000_2025.06.11.659008v1.55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013989"},{"key":"2026041203343581000_2025.06.11.659008v1.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.06.009"},{"key":"2026041203343581000_2025.06.11.659008v1.57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000599"},{"key":"2026041203343581000_2025.06.11.659008v1.58","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230746"},{"key":"2026041203343581000_2025.06.11.659008v1.59","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1467333"},{"key":"2026041203343581000_2025.06.11.659008v1.60","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-014-9538-8"},{"key":"2026041203343581000_2025.06.11.659008v1.61","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01104-7"},{"key":"2026041203343581000_2025.06.11.659008v1.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.05.023"},{"key":"2026041203343581000_2025.06.11.659008v1.63","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3029"},{"key":"2026041203343581000_2025.06.11.659008v1.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.10.005"},{"key":"2026041203343581000_2025.06.11.659008v1.65","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00016"},{"key":"2026041203343581000_2025.06.11.659008v1.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.102141"},{"key":"2026041203343581000_2025.06.11.659008v1.67","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0543-y"},{"key":"2026041203343581000_2025.06.11.659008v1.68","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0372-9"},{"key":"2026041203343581000_2025.06.11.659008v1.69","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03995-1"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.06.11.659008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T10:34:45Z","timestamp":1775990085000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.06.11.659008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,15]]},"references-count":69,"URL":"https:\/\/doi.org\/10.1101\/2025.06.11.659008","relation":{},"subject":[],"published":{"date-parts":[[2025,6,15]]},"subtype":"preprint"}}