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Whether brown fat has a causal role in this process and the underlying molecular mechanisms remain unknown. Here we investigate the role of murine beige fat, as a model of inducible brown fat in humans, in adipocyte-vascular crosstalk. Using mice with an adipocyte-specific deletion of PRDM16, resulting in a loss of beige adipocyte identity, we discover a dramatic remodeling of perivascular adipose tissue, increased vascular reactivity and elevated blood pressure. We further show that the circulating enzyme\n                  <jats:italic>Qsox1<\/jats:italic>\n                  is de-repressed in\n                  <jats:italic>Prdm16<\/jats:italic>\n                  -deficient adipocytes, and deletion of\n                  <jats:italic>Qsox1<\/jats:italic>\n                  in PRDM16cKO mice rescues vascular fibrosis and reactivity. These results demonstrate a key new role for beige adipocytes in blood pressure regulation and identify\n                  <jats:italic>Qsox1<\/jats:italic>\n                  as an important mediator of adipocyte-vascular crosstalk.\n                <\/jats:p>","DOI":"10.1101\/2025.06.12.658904","type":"posted-content","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T19:25:11Z","timestamp":1750188311000},"source":"Crossref","is-referenced-by-count":1,"title":["Ablation of\n                  <i>Prdm16<\/i>\n                  and beige fat causes vascular remodeling and elevated blood pressure"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1024-4506","authenticated-orcid":false,"given":"Mascha","family":"Koenen","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Metabolism, The Rockefeller University; New York, NY, 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Becher","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Metabolism, The Rockefeller University; 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