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Seventy-one genes were differentially methylated between persons with AD and CU, and 132 genes were differentially methylated between persons with MCI and AD. Thirteen differentially methylated genes shared between the 3 comparisons support contributions from disrupted metabolism and oxidative stress pathways in AD pathogenesis.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Nuclear genes that encode proteins that participate in mitochondrial glucose metabolism, fatty acid metabolism and oxidative stress pathways are differentially methylated between persons who are CU and those with MCI and AD.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.06.16.659556","type":"posted-content","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:50:16Z","timestamp":1750467016000},"source":"Crossref","is-referenced-by-count":1,"title":["Differential DNA methylation in blood in nuclear genes that encode mitochondrial proteins in mild cognitive impairment and Alzheimer\u2019s disease"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8825-3763","authenticated-orcid":false,"given":"Alexander E.","family":"Boruch","sequence":"first","affiliation":[{"name":"William S. 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