{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:09:52Z","timestamp":1792786192432,"version":"4.5.0"},"posted":{"date-parts":[[2025,6,17]]},"group-title":"Genetic and Genomic Medicine","reference-count":57,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"award":["2019-01004"],"award-info":[{"award-number":["2019-01004"]}],"id":[{"id":"https:\/\/ror.org\/03zttf063","id-type":"ROR","asserted-by":"publisher"}]},{"award":["2024-02502"],"award-info":[{"award-number":["2024-02502"]}],"id":[{"id":"https:\/\/ror.org\/03zttf063","id-type":"ROR","asserted-by":"publisher"}]},{"award":["2023-02735"],"award-info":[{"award-number":["2023-02735"]}],"id":[{"id":"https:\/\/ror.org\/03zttf063","id-type":"ROR","asserted-by":"publisher"}]},{"name":"The Research Council of Norway","award":["547711"],"award-info":[{"award-number":["547711"]}],"id":[{"id":"https:\/\/ror.org\/00epmv149","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Research Council of Norway","award":["240413"],"award-info":[{"award-number":["240413"]}],"id":[{"id":"https:\/\/ror.org\/00epmv149","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Research Council of Norway","award":["274611"],"award-info":[{"award-number":["274611"]}],"id":[{"id":"https:\/\/ror.org\/00epmv149","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Research Council of Norway","award":["301178"],"award-info":[{"award-number":["301178"]}],"id":[{"id":"https:\/\/ror.org\/00epmv149","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Research Council of Norway","award":["315599"],"award-info":[{"award-number":["315599"]}],"id":[{"id":"https:\/\/ror.org\/00epmv149","id-type":"ROR","asserted-by":"crossref"}]},{"name":"March of Dimes","award":["21-FY16-121"],"award-info":[{"award-number":["21-FY16-121"]}],"id":[{"id":"https:\/\/ror.org\/04bd5p711","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Agreement concerning research and education of doctors ALF","award":["ALFGBG-965353"],"award-info":[{"award-number":["ALFGBG-965353"]}]},{"name":"Agreement concerning research and education of doctors ALF","award":["ALFGBG-1005151"],"award-info":[{"award-number":["ALFGBG-1005151"]}]},{"name":"Agreement concerning research and education of doctors ALF","award":["ALFGBG-1005149"],"award-info":[{"award-number":["ALFGBG-1005149"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["R01HD101669"],"award-info":[{"award-number":["R01HD101669"]}],"id":[{"id":"https:\/\/ror.org\/04byxyr05","id-type":"ROR","asserted-by":"crossref"}]},{"name":"European Research Council","award":["293574"],"award-info":[{"award-number":["293574"]}],"id":[{"id":"https:\/\/ror.org\/0472cxd90","id-type":"ROR","asserted-by":"crossref"}]},{"name":"European Research Council","award":["101171420"],"award-info":[{"award-number":["101171420"]}],"id":[{"id":"https:\/\/ror.org\/0472cxd90","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Novo Nordisk Foundation","award":["54741"],"award-info":[{"award-number":["54741"]}],"id":[{"id":"https:\/\/ror.org\/04txyc737","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Novo Nordisk Foundation","award":["NNF20OC0063872"],"award-info":[{"award-number":["NNF20OC0063872"]}],"id":[{"id":"https:\/\/ror.org\/04txyc737","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Swedish Society for Medical Research","award":["SG-24-0105-B"],"award-info":[{"award-number":["SG-24-0105-B"]}],"id":[{"id":"https:\/\/ror.org\/0433fd238","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Southern and Eastern Norway Regional Health Authority","award":["2021045"],"award-info":[{"award-number":["2021045"]}],"id":[{"id":"https:\/\/ror.org\/02qx2s478","id-type":"ROR","asserted-by":"crossref"}]},{"award":["MC_UU_00032\/1"],"award-info":[{"award-number":["MC_UU_00032\/1"]}],"id":[{"id":"https:\/\/ror.org\/03x94j517","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Helse Vest","award":["912250"],"award-info":[{"award-number":["912250"]}]},{"name":"Helse Vest","award":["F-12144"],"award-info":[{"award-number":["F-12144"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Gestational duration and birth weight are linked to adverse health outcomes in offspring and mothers. Previous genome-wide association studies (GWAS) on these pregnancy outcomes did not consider parity, despite its known effects on mean values and variance. Here, we explored whether nulliparity (no previous births) modified the maternal or fetal genetic effects on gestational duration and birth weight, and resolved effect origin in up to 58,528 mothers and fetuses from the Norwegian Mother, Father, and Child Cohort Study. We identified shared and distinct loci for each outcome in parity-stratified GWAS. For gestational duration, we identified more maternal loci in nulliparous women, and a polygenic predictor had a three-fold higher prediction accuracy among nulliparous compared to multiparous women (p-value interaction = 5\u00d710\n                  <jats:sup>\u22125<\/jats:sup>\n                  ), with validation in an independent cohort. The results for birth weight showed discrepancies between the number of loci and the polygenic predictor. Our study reveals that nulliparity modifies the maternal genetic effects on gestational duration and highlights the relevance of considering nulliparity in genetic, and likely experimental, studies on pregnancy outcomes.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>Teaser<\/jats:title>\n                  <jats:p>Genome-wide study highlights that maternal genetics affect pregnancy length more strongly in first pregnancy.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.06.17.25329777","type":"posted-content","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:10:10Z","timestamp":1750205410000},"source":"Crossref","is-referenced-by-count":1,"title":["Nulliparity modifies the maternal genetic effects on gestational duration but not on birth weight"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4314-1546","authenticated-orcid":false,"given":"Karin","family":"Ytterberg","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedvig","family":"Sundelin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7844-1397","authenticated-orcid":false,"given":"Xiaoping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5600-974X","authenticated-orcid":false,"given":"Julius","family":"Juodakis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1179-9578","authenticated-orcid":false,"given":"Marc","family":"Vaudel","sequence":"additional","affiliation":[{"name":"Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway"},{"name":"Department of Genetics and Bioinformatics, Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0119-157X","authenticated-orcid":false,"given":"Elizabeth C.","family":"Corfield","sequence":"additional","affiliation":[{"name":"PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway"},{"name":"Psychiatric Genetic Epidemiology Group, Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway"},{"name":"MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4461-3568","authenticated-orcid":false,"given":"Ole A.","family":"Andreassen","sequence":"additional","affiliation":[{"name":"NORMENT Centre, University of Oslo, Oslo, Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6427-4735","authenticated-orcid":false,"given":"Per","family":"Magnus","sequence":"additional","affiliation":[{"name":"Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9268-0423","authenticated-orcid":false,"given":"Alexandra","family":"Havdahl","sequence":"additional","affiliation":[{"name":"PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway"},{"name":"Psychiatric Genetic Epidemiology Group, Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway"},{"name":"PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4748-0446","authenticated-orcid":false,"given":"Staffan","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0304-6728","authenticated-orcid":false,"given":"P\u00e5l R.","family":"Nj\u00f8lstad","sequence":"additional","affiliation":[{"name":"Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway"},{"name":"Department of Pediatrics and Adolescents Medicine, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2298-7008","authenticated-orcid":false,"given":"Stefan","family":"Johansson","sequence":"additional","affiliation":[{"name":"Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway"},{"name":"Department of Pediatrics and Adolescents Medicine, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5079-2374","authenticated-orcid":false,"given":"Bo","family":"Jacobsson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"},{"name":"Department of Genetics and Bioinformatics, Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway"},{"name":"Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, V\u00e4stra G\u00f6taland Region, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3326-266X","authenticated-orcid":false,"given":"Pol","family":"Sol\u00e9-Navais","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"},{"name":"Wallenberg Laboratory\/ Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026101521150784000_2025.06.17.25329777v2.1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S2352-4642(21)00311-4","article-title":"Global, regional, and national causes of under-5 mortality in 2000-19: an updated systematic analysis with implications for the Sustainable Development Goals","volume":"6","year":"2022","journal-title":"Lancet Child Adolesc Health"},{"key":"2026101521150784000_2025.06.17.25329777v2.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00896-x"},{"key":"2026101521150784000_2025.06.17.25329777v2.3","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1093\/hmg\/ddad086","article-title":"Time-varying effects are common in genetic control of gestational duration","volume":"32","year":"2023","journal-title":"Hum Mol Genet"},{"key":"2026101521150784000_2025.06.17.25329777v2.4","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1038\/s41467-019-11881-8","article-title":"Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration","volume":"10","year":"2019","journal-title":"Nature Communications"},{"key":"2026101521150784000_2025.06.17.25329777v2.5","doi-asserted-by":"crossref","first-page":"e1010982","DOI":"10.1371\/journal.pgen.1010982","article-title":"Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci","volume":"19","year":"2023","journal-title":"PLOS Genetics"},{"key":"2026101521150784000_2025.06.17.25329777v2.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01343-9"},{"key":"2026101521150784000_2025.06.17.25329777v2.7","doi-asserted-by":"crossref","unstructured":"K. Ytterberg , B. Jacobsson , C. Flatley , J. Juodakis , S. Nilsson , P. Sol\u00e9-Navais , Exploring the association of parity and its interaction with history of preterm delivery on gestational duration. Annals of Epidemiology, (2023).","DOI":"10.1101\/2023.02.16.23286023"},{"key":"2026101521150784000_2025.06.17.25329777v2.8","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1997)14:4<423::AID-GEPI7>3.0.CO;2-3"},{"key":"2026101521150784000_2025.06.17.25329777v2.9","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12099"},{"key":"2026101521150784000_2025.06.17.25329777v2.10","doi-asserted-by":"crossref","first-page":"155758","DOI":"10.1016\/j.cyto.2021.155758","article-title":"Inflammatory and immune marker trajectories from pregnancy to one-year post-birth","volume":"149","year":"2022","journal-title":"Cytokine"},{"key":"2026101521150784000_2025.06.17.25329777v2.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.03.030"},{"key":"2026101521150784000_2025.06.17.25329777v2.12","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/AOG.0b013e3181e6cc10","article-title":"Width of the Normal Uterine Cavity in Premenopausal Women and Effect of Parity","volume":"116","year":"2010","journal-title":"Obstetrics & Gynecology"},{"key":"2026101521150784000_2025.06.17.25329777v2.13","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41398-021-01288-9","article-title":"Genome-wide gene-environment interactions in neuroticism: an exploratory study across 25 environments","volume":"11","year":"2021","journal-title":"Translational Psychiatry"},{"key":"2026101521150784000_2025.06.17.25329777v2.14","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.bpsgos.2021.11.003","article-title":"Genome-wide by Environment Interaction Study of Stressful Life Events and Hospital-Treated Depression in the iPSYCH2012 Sample","volume":"2","year":"2022","journal-title":"Biological Psychiatry Global Open Science"},{"key":"2026101521150784000_2025.06.17.25329777v2.15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41398-018-0360-y","article-title":"C. Major Depressive Disorder Working Group of the Psychiatric Genomics, Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland","volume":"9","year":"2019","journal-title":"Translational Psychiatry"},{"key":"2026101521150784000_2025.06.17.25329777v2.16","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41576-019-0137-z","article-title":"Genetic correlations of polygenic disease traits: from theory to practice","volume":"20","year":"2019","journal-title":"Nature Reviews Genetics"},{"key":"2026101521150784000_2025.06.17.25329777v2.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mppsy.2008.10.002"},{"key":"2026101521150784000_2025.06.17.25329777v2.18","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0546-6"},{"key":"2026101521150784000_2025.06.17.25329777v2.19","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1038\/s41598-020-60032-3","article-title":"Interactions between a Polygenic Risk Score and Non-genetic Risk Factors in Young-Onset Breast Cancer","volume":"10","year":"2020","journal-title":"Scientific Reports"},{"key":"2026101521150784000_2025.06.17.25329777v2.20","doi-asserted-by":"publisher","DOI":"10.2290\/genes5020330"},{"key":"2026101521150784000_2025.06.17.25329777v2.21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203039"},{"key":"2026101521150784000_2025.06.17.25329777v2.22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2204069119"},{"key":"2026101521150784000_2025.06.17.25329777v2.23","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.1160940"},{"key":"2026101521150784000_2025.06.17.25329777v2.24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058257"},{"key":"2026101521150784000_2025.06.17.25329777v2.25","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3185"},{"key":"2026101521150784000_2025.06.17.25329777v2.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2024.10.018"},{"key":"2026101521150784000_2025.06.17.25329777v2.27","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13058-016-0748-7","article-title":"WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines","volume":"18","year":"2016","journal-title":"Breast Cancer Res"},{"key":"2026101521150784000_2025.06.17.25329777v2.28","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3419"},{"key":"2026101521150784000_2025.06.17.25329777v2.29","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612665"},{"key":"2026101521150784000_2025.06.17.25329777v2.30","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3211"},{"key":"2026101521150784000_2025.06.17.25329777v2.31","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3406"},{"key":"2026101521150784000_2025.06.17.25329777v2.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2025.01.014"},{"key":"2026101521150784000_2025.06.17.25329777v2.33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-44489-6"},{"key":"2026101521150784000_2025.06.17.25329777v2.34","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/s41467-024-45338-4","article-title":"A common allele increases endometrial Wnt4 expression, with antagonistic implications for pregnancy, reproductive cancers, and endometriosis","volume":"15","year":"2024","journal-title":"Nature Communications"},{"key":"2026101521150784000_2025.06.17.25329777v2.35","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2010-3800"},{"key":"2026101521150784000_2025.06.17.25329777v2.36","doi-asserted-by":"crossref","first-page":"27915","DOI":"10.1038\/s41598-025-10415-1","article-title":"Maternal parity modifies the association of birthweight polygenic score with fetal growth","volume":"15","year":"2025","journal-title":"Scientific Reports"},{"key":"2026101521150784000_2025.06.17.25329777v2.37","doi-asserted-by":"crossref","unstructured":"R. E. Brandlistuen , D. Kristjansson , E. Alsaker , R. Valen , E. Birkeland , E. C. R\u00f8yrvik , C. M. Page , M. Aamelfot , S. Vangb\u00e6k , H. Ask , A. Havdahl , A. L. Brants\u00e6ter , G. Rortveit , S. E. H\u00e5berg , P. Magnus , Cohort Profile Update: The Norwegian Mother, Father and Child Cohort (MoBa). International Journal of Epidemiology 54, (2025).","DOI":"10.1093\/ije\/dyaf139"},{"key":"2026101521150784000_2025.06.17.25329777v2.38","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw029"},{"key":"2026101521150784000_2025.06.17.25329777v2.39","doi-asserted-by":"crossref","unstructured":"L. Paltiel , H. Anita , T. Skjerden , K. Harbak , S. B\u00e6kken , S. Nina Kristin , G. P. Knudsen , P. Magnus , The biobank of the Norwegian Mother and Child Cohort Study \u2013 present status. Norsk Epidemiologi 24, (2014).","DOI":"10.5324\/nje.v24i1-2.1755"},{"key":"2026101521150784000_2025.06.17.25329777v2.40","first-page":"435","article-title":"The Medical Birth Registry of Norway","volume":"79","year":"2000","journal-title":"Epidemiological research and surveillance throughout 30 years. Acta Obstet Gynecol Scand"},{"key":"2026101521150784000_2025.06.17.25329777v2.41","doi-asserted-by":"crossref","unstructured":"E. C. Corfield , A. A. Shadrin , O. Frei , Z. Rahman , B. C. Akdeniz , T. T. Filiz , A. Lin , I. Badini , L. Hegemann , L. Athanasiu , R. E. Wootton , C. Austerberry , A. M. Hughes , M. Tesli , E. Hagen , R. E. Brandlistuen , E. M. Eilertsen , L. T. Westlye , P. R. Nj\u00f8lstad , P. Magnus , E. Hovig , T. Zayats , H. Ask , T. Reichborn-Kjennerud , G. Hemani , N. M. Davies , L. J. Hannigan , O. A. Andreassen , A. K. Havdahl , Family genetic designs in MoBa provide insights into health and functioning. Nature, (2026).","DOI":"10.1038\/s41586-026-10926-5"},{"key":"2026101521150784000_2025.06.17.25329777v2.42","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq559"},{"key":"2026101521150784000_2025.06.17.25329777v2.43","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys064"},{"key":"2026101521150784000_2025.06.17.25329777v2.44","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys066"},{"key":"2026101521150784000_2025.06.17.25329777v2.45","doi-asserted-by":"publisher","DOI":"10.1038\/S41588-021-00870-7"},{"key":"2026101521150784000_2025.06.17.25329777v2.46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003305"},{"key":"2026101521150784000_2025.06.17.25329777v2.47","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01415-w"},{"key":"2026101521150784000_2025.06.17.25329777v2.48","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/bioinformatics\/btx561","article-title":"LDassoc: an online tool for interactively exploring genome-wide association study results and prioritizing variants for functional investigation","volume":"34","year":"2018","journal-title":"Bioinformatics"},{"key":"2026101521150784000_2025.06.17.25329777v2.49","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00924-w"},{"key":"2026101521150784000_2025.06.17.25329777v2.50","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/s41598-023-28172-4","article-title":"Efficient gene\u2013environment interaction testing through bootstrap aggregating","volume":"13","year":"2023","journal-title":"Scientific Reports"},{"key":"2026101521150784000_2025.06.17.25329777v2.51","first-page":"1","article-title":"ranger: A Fast Implementation of Random Forests for High Dimensional Data in C++ and R","volume":"77","year":"2017","journal-title":"Journal of Statistical Software"},{"key":"2026101521150784000_2025.06.17.25329777v2.52","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1038\/s41467-019-09718-5","article-title":"Polygenic prediction via Bayesian regression and continuous shrinkage priors","volume":"10","year":"2019","journal-title":"Nature Communications"},{"key":"2026101521150784000_2025.06.17.25329777v2.53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.12688\/f1000research.29032.2","article-title":"Sustainable data analysis with Snakemake","volume":"10","year":"2021","journal-title":"F1000Res"},{"key":"2026101521150784000_2025.06.17.25329777v2.54","unstructured":"Anaconda Software Distribution [Internet]. Anaconda Documentation. Anaconda Inc.; 2020. Available from: https:\/\/docs.anaconda.com\/."},{"key":"2026101521150784000_2025.06.17.25329777v2.55","doi-asserted-by":"crossref","unstructured":"N. Khader , A. Dorogin , O. Shynlova , J. A. Mitchell , JUND plays a genome-wide role in the quiescent to contractile switch in the pregnant human myometrium. bioRxiv, 2024.2004.2016.589699 (2024).","DOI":"10.1101\/2024.04.16.589699"},{"key":"2026101521150784000_2025.06.17.25329777v2.56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201904"},{"key":"2026101521150784000_2025.06.17.25329777v2.57","doi-asserted-by":"publisher","DOI":"10.4236\/ojs.2011.13024"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.06.17.25329777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:15:20Z","timestamp":1792124120000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2025.06.17.25329777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,17]]},"references-count":57,"URL":"https:\/\/doi.org\/10.1101\/2025.06.17.25329777","relation":{},"subject":[],"published":{"date-parts":[[2025,6,17]]},"subtype":"preprint"}}