{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:57:36Z","timestamp":1782280656090,"version":"3.54.5"},"posted":{"date-parts":[[2025,6,25]]},"group-title":"Neuroscience","reference-count":165,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH\/NIA","award":["R01AG075998"],"award-info":[{"award-number":["R01AG075998"]}]},{"name":"NIH\/NIA","award":["R01AG056478"],"award-info":[{"award-number":["R01AG056478"]}]},{"name":"NIH\/NIA","award":["R01AG055865"],"award-info":[{"award-number":["R01AG055865"]}]},{"name":"NIH\/NIA","award":["AG056478-04S1"],"award-info":[{"award-number":["AG056478-04S1"]}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"crossref","award":["AARG-NTF-21-846586"],"award-info":[{"award-number":["AARG-NTF-21-846586"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  <jats:italic>Chlamydia pneumoniae<\/jats:italic>\n                  (Cp), an obligate intracellular bacterium, has been implicated in Alzheimer\u2019s disease (AD), yet its role in retinal pathology remains unexplored. We analyzed postmortem tissues from 95 human donors and found 2.9-4.1-fold increases in Cp inclusions in AD retinas and brains, with no significant elevation in mild cognitive impairment (MCI). Proteomics revealed dysregulation of retinal and brain bacterial infection-related proteins and NLRP3 inflammasome pathways. NLRP3 expression was markedly elevated in MCI and AD retinas, and its activation was evident by increased N-terminal gasdermin D (NGSDMD) and mature interleukin-1\u03b2. Retinal Cp strongly correlated with A\u03b2\n                  <jats:sub>42<\/jats:sub>\n                  and NLRP3 inflammasome components, which tightly linked to cleaved caspase-3-apoptotic and NGSDMD-pyroptotic cell death. Although retinal microgliosis was elevated in AD, Cp-associated microglia were reduced by 62%, suggesting impaired Cp phagocytosis. Higher retinal Cp burden correlated with APOE\u03b54, Braak stage, and cognitive deficit. Machine learning identified retinal Cp or NLRP3 combined with A\u03b2\n                  <jats:sub>42<\/jats:sub>\n                  as strong predictors of AD diagnosis, staging, and cognitive impairment. Our findings suggest that Cp infection contributes to AD dementia but not initiating pathology, whereas early NLRP3 activation may promote disease development, warranting studies on Cp\u2019s role in AD pathogenesis and early antibiotic or inflammasome-targeted therapies.\n                <\/jats:p>","DOI":"10.1101\/2025.06.19.660619","type":"posted-content","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T09:30:12Z","timestamp":1750843812000},"source":"Crossref","is-referenced-by-count":1,"title":["Identification of\n                  <i>Chlamydia pneumoniae<\/i>\n                  and NLRP3 inflammasome activation in Alzheimer\u2019s disease retina"],"prefix":"10.64898","author":[{"given":"Bhakta Prasad","family":"Gaire","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 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