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Chen graduate fellowship: Lehigh University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Gastric function is regulated by the gut-brain axis, which integrates vagal and\n                  <jats:underline>enteric nervous system (ENS)<\/jats:underline>\n                  pathways. The parasympathetic circuit within the vagal pathway promotes digestion by stimulating peristaltic activity and relaxing the\n                  <jats:underline>Pyloric sphincter (PS)<\/jats:underline>\n                  through motor and sensory neurons. In contrast, the sympathetic pathway inhibits digestion by suppressing peristalsis and constricting the\n                  <jats:underline>PS,<\/jats:underline>\n                  highlighting the complex neural coordination involved in gastric regulation.\n                <\/jats:p>\n                <jats:p>\n                  This study introduces a novel mathematical model of the gut-brain axis using a computationally efficient compartmental framework. The model simulates the vagal and\n                  <jats:underline>ENS<\/jats:underline>\n                  pathways and their corresponding effects on gastric function to improve our understanding of gut-brain axis regulation. The model employs the\n                  <jats:underline>Michaelis-Menten equation with a Hill coefficient (MMEHC)<\/jats:underline>\n                  equation to capture neurotransmitter release at neuromuscular junctions by stimulation of motor neurons and its effects on gastric cells. Motor (efferent) neurons are modeled for three key stomach regions: the fundus (tonic activity), antrum (phasic activity), and\n                  <jats:underline>PS<\/jats:underline>\n                  (both tonic and phasic activity). Thus, the stomach is represented as a three-compartment model.\n                <\/jats:p>\n                <jats:p>The stomach model extends our previous work (Fernandes et al., 2024) by incorporating passive stress and dynamic changes in stomach geometry. Sensory (afferent) inputs are represented through linear equations that account for chemo- and mechanoreceptor activity, while a binary variable captures the sympathetic response. Afferent and efferent firing rates are linked via fitted curves to effectively close the gut-brain axis feedback loop, borrowing from a similar approach used to model cardiovascular regulation.<\/jats:p>\n                <jats:p>\n                  The simulation results align with physiological observations, demonstrating inhibitory digestive activity during sympathetic responses and excitatory activity, such as gastric emptying, during parasympathetic responses. During gastric emptying, the\n                  <jats:underline>Interstitial Cells of Cajal (ICC)<\/jats:underline>\n                  activity shows constant amplitude for low to medium gastric volumes but exhibits an increase in amplitude at very high gastric volumes. Furthermore, gastric emptying rates decrease with high-calorie liquids due to\n                  <jats:underline>PS<\/jats:underline>\n                  regulation, validating the potential of the model for studying\n                  <jats:underline>Gastrointestinal (GI)<\/jats:underline>\n                  disorders and developing vagal-based therapies.\n                <\/jats:p>","DOI":"10.1101\/2025.06.19.660643","type":"posted-content","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T01:20:18Z","timestamp":1750900818000},"source":"Crossref","is-referenced-by-count":1,"title":["A Compartmental Model for Simulating the Gut-Brain Axis in Gastric Function Regulation"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6186-5162","authenticated-orcid":false,"given":"Shannon Q","family":"Fernandes","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA, 18015, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7681-7445","authenticated-orcid":false,"given":"Mayuresh V","family":"Kothare","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA, 18015, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026041210114936000_2025.06.19.660643v1.1","unstructured":"J. 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