{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:35:24Z","timestamp":1783427724758,"version":"3.54.6"},"posted":{"date-parts":[[2025,6,23]]},"group-title":"Dermatology","reference-count":65,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,6,23]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Data from family and twin studies as well as prior genome-wide association meta- analyses suggest that hidradenitis suppurativa (HS) has a hereditary component.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Identify genetic variants associated with HS.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A case-control genome-wide association study (GWAS) was performed on participants with a diagnosis of HS defined as at least one instance of ICD9 705.83 or ICD10 L73.2 from participants in the VA\u2019s Million Veteran Program.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    4,959 participants with HS were identified among 597,819 MVP participants. The multi-population GWAS identified two significant loci associated with HS, including a novel HS- related variant on chromosome 6 near\n                    <jats:italic>HLA-DRB1<\/jats:italic>\n                    (lead variant rs679242), and confirmed a previously identified locus on chromosome 17 near\n                    <jats:italic>SOX9<\/jats:italic>\n                    (rs55811634). The following previously identified loci achieved suggestive evidence for association (p&lt;1x10\n                    <jats:sup>-3<\/jats:sup>\n                    ): rs17090189 (near\n                    <jats:italic>KLF5<\/jats:italic>\n                    ), rs121908120 (2q35), rs10816701 (9q31.3), rs17090189 (13q22.1), and rs17103088 (14q24.3).\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>\n                    The analysis of the MVP resource for HS identified a novel signal on chromosome 6 near\n                    <jats:italic>HLA-DRB1<\/jats:italic>\n                    , and identified significant evidence and suggestive evidence for several previously reported signals for HS.\n                  <\/jats:p>\n                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