{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:44:00Z","timestamp":1788965040284,"version":"build-2803163510"},"posted":{"date-parts":[[2025,6,26]]},"group-title":"Cancer Biology","reference-count":71,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["R00CA188679"],"award-info":[{"award-number":["R00CA188679"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R37CA248565"],"award-info":[{"award-number":["R37CA248565"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]},{"award":["F31CA246811"],"award-info":[{"award-number":["F31CA246811"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]},{"award":["K08CA237871"],"award-info":[{"award-number":["K08CA237871"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]},{"award":["F31CA275321"],"award-info":[{"award-number":["F31CA275321"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]},{"award":["1F31CA281083"],"award-info":[{"award-number":["1F31CA281083"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["R01DK125263"],"award-info":[{"award-number":["R01DK125263"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"award":["F32AG077861"],"award-info":[{"award-number":["F32AG077861"]}],"id":[{"id":"https:\/\/ror.org\/049v75w11","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014008","name":"Ovarian Cancer Research Alliance","doi-asserted-by":"crossref","award":["CRDG-2023-3-1001"],"award-info":[{"award-number":["CRDG-2023-3-1001"]}],"id":[{"id":"10.13039\/100014008","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001445","name":"Alex's Lemonade Stand Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100016610","name":"Andrew McDonough B+ Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016610","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Paclitaxel and other microtubule-targeting agents are cornerstone therapies for diverse cancers, including lung, breast, cervical, pancreatic, and ovarian malignancies. Paclitaxel induces tumor cell apoptosis during mitosis by disrupting microtubule dynamics required for chromosome segregation. However, despite initial responsiveness, many tumors develop resistance, limiting therapeutic durability. Here, we used high-grade serous ovarian carcinoma (HGSOC), the most common and lethal subtype of ovarian cancer, as a model to dissect the mechanisms underlying this resistance. We find that paclitaxel-induced mitotic arrest triggers degradation of the pro-survival protein MCL-1 and upregulation of BCL-XL, followed by inactivating phosphorylation of BCL-XL at Ser62 to promote apoptosis. In resistant cells, this MCL-1 downregulation is insufficient to commit cells to apoptosis but instead results in a transient convergence of apoptotic dependencies by forcing BCL-X\n                  <jats:sub>L<\/jats:sub>\n                  to sequester the pro-apoptotic proteins BIM, BAX, and BAK. During this state, BCL-XL inhibition induces synergistic apoptosis, even in chemoresistant cells. Surprisingly, we also discover that loss of substrate attachment recapitulates this apoptotic convergence both in vitro and in vivo, with HGSOC cells growing in metastasis-promoting malignant ascites displaying heightened apoptotic priming and dependence on BCL-XL relative to solid tumors. In HGSOC xenografts, targeted degradation of BCL-XL using the platelet-sparing proteolysis-targeting chimera (PROTAC) DT2216 matches the efficacy of paclitaxel monotherapy while avoiding the chronic thrombocytopenia induced by BCL-XL inhibitors such as navitoclax (ABT-263). Strikingly, combination therapy leveraging the synergy between paclitaxel and DT2216 leads to complete eradication of HGSOC cell line and patient-derived xenografts. Moreover, DT2216 treatment blunts the rapid apoptotic adaptation caused by other BCL-X\n                  <jats:sub>L<\/jats:sub>\n                  inhibitors, indicating that targeted degradation of pro-survival proteins may yield more durable responses than inhibition alone. These findings uncover a mechanistic framework for safely exploiting the apoptotic dependency convergence caused by mitotic arrest and substrate detachment and support the clinical development of BCL-XL\u2013targeting PROTACs to overcome chemoresistance in ovarian cancer and other solid tumors.\n                <\/jats:p>","DOI":"10.1101\/2025.06.24.661170","type":"posted-content","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T17:50:15Z","timestamp":1750960215000},"source":"Crossref","is-referenced-by-count":11,"title":["Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-X\n                  <sub>L<\/sub>\n                  degradation to overcome cancer chemoresistance"],"prefix":"10.64898","author":[{"given":"Xingping","family":"Qin","sequence":"first","affiliation":[{"name":"John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA"},{"name":"Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA"},{"name":"Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Presser","sequence":"additional","affiliation":[{"name":"John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA"},{"name":"Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA"},{"name":"Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lissah","family":"Johnson","sequence":"additional","affiliation":[{"name":"John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA"},{"name":"Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA"},{"name":"Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Matoba","sequence":"additional","affiliation":[{"name":"Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA"},{"name":"Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan S.","family":"Shay","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA"},{"name":"Ludwig Center at Harvard, Harvard Medical School Boston, Boston, Ma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA"},{"name":"Ludwig Center at Harvard, Harvard Medical School Boston, Boston, Ma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Choiniere","sequence":"additional","affiliation":[{"name":"John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA"},{"name":"Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA"},{"name":"Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Fraser","sequence":"additional","affiliation":[{"name":"John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA"},{"name":"Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA"},{"name":"Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5548-1564","authenticated-orcid":false,"given":"Filip","family":"Garbicz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"Department of Immunology, Medical University of Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Spetz","sequence":"additional","affiliation":[{"name":"John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA"},{"name":"Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA"},{"name":"Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Yu","sequence":"additional","affiliation":[{"name":"John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA"},{"name":"Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA"},{"name":"Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary H. C.","family":"Florido","sequence":"additional","affiliation":[{"name":"John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA"},{"name":"Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA"},{"name":"Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Picucci","sequence":"additional","affiliation":[{"name":"John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA"},{"name":"Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA"},{"name":"Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"University of Texas San Antonio, San Antonio, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-6977","authenticated-orcid":false,"given":"Ronny","family":"Drapkin","sequence":"additional","affiliation":[{"name":"Penn Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA"},{"name":"Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA"},{"name":"Department of Medicine, Harvard Medical School, Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA"},{"name":"Department of Medicine, Harvard Medical School, Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Matulonis","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA"},{"name":"Department of Medicine, Harvard Medical School, Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Brugge","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA"},{"name":"Ludwig Center at Harvard, Harvard Medical School Boston, Boston, Ma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo R.","family":"Rueda","sequence":"additional","affiliation":[{"name":"Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA"},{"name":"Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daohong","family":"Zhou","sequence":"additional","affiliation":[{"name":"University of Texas San Antonio, San Antonio, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth H.","family":"Stover","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA"},{"name":"Department of Medicine, Harvard Medical School, Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4618-5085","authenticated-orcid":false,"given":"Kristopher A.","family":"Sarosiek","sequence":"additional","affiliation":[{"name":"John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA"},{"name":"Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Department of Systems Biology, Harvard Medical School, Boston, MA"},{"name":"Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health; Boston MA"},{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026041210220580000_2025.06.24.661170v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2013.11.009"},{"key":"2026041210220580000_2025.06.24.661170v1.2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0857"},{"key":"2026041210220580000_2025.06.24.661170v1.3","unstructured":"Verhaak, R. G. W. et al. Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. 123, 517\u2013525 (2013)."},{"key":"2026041210220580000_2025.06.24.661170v1.4","doi-asserted-by":"publisher","DOI":"10.1038\/nature10166"},{"key":"2026041210220580000_2025.06.24.661170v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.207"},{"key":"2026041210220580000_2025.06.24.661170v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1123"},{"key":"2026041210220580000_2025.06.24.661170v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.08.017"},{"key":"2026041210220580000_2025.06.24.661170v1.8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209608"},{"key":"2026041210220580000_2025.06.24.661170v1.9","doi-asserted-by":"crossref","unstructured":"Johnstone, R. W. , Ruefli, A. A. , Lowe, S. W. & Victoria, E. M . ApoptosislJ: A Link between Cancer Genetics and Chemotherapy Defects in apoptosis underpin both tumorigenesis and. 108, 153\u2013164 (2002).","DOI":"10.1016\/S0092-8674(02)00625-6"},{"key":"2026041210220580000_2025.06.24.661170v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2013.08.003"},{"key":"2026041210220580000_2025.06.24.661170v1.11","doi-asserted-by":"crossref","unstructured":"Campbell, K. J. & Tait, S. W. G . Targeting BCL-2 regulated apoptosis in cancer. 1\u201311 (2018).","DOI":"10.1098\/rsob.180002"},{"key":"2026041210220580000_2025.06.24.661170v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/35037734"},{"key":"2026041210220580000_2025.06.24.661170v1.13","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701320337"},{"key":"2026041210220580000_2025.06.24.661170v1.14","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.85"},{"key":"2026041210220580000_2025.06.24.661170v1.15","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.031682"},{"key":"2026041210220580000_2025.06.24.661170v1.16","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3076"},{"key":"2026041210220580000_2025.06.24.661170v1.17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1206727"},{"key":"2026041210220580000_2025.06.24.661170v1.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.08.048"},{"key":"2026041210220580000_2025.06.24.661170v1.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.01.042"},{"key":"2026041210220580000_2025.06.24.661170v1.20","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-016-0234-y"},{"key":"2026041210220580000_2025.06.24.661170v1.21","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0693"},{"key":"2026041210220580000_2025.06.24.661170v1.22","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-18-1243"},{"key":"2026041210220580000_2025.06.24.661170v1.23","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.3914"},{"key":"2026041210220580000_2025.06.24.661170v1.24","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2583"},{"key":"2026041210220580000_2025.06.24.661170v1.25","doi-asserted-by":"crossref","unstructured":"Al-Alem, L. F. , Baker, A. T. , Pandya, U. M. , Eisenhauer, E. L. & Rueda, B. R . Understanding and targeting apoptotic pathways in ovarian cancer. Cancers 11, (2019).","DOI":"10.3390\/cancers11111631"},{"key":"2026041210220580000_2025.06.24.661170v1.26","first-page":"197","volume-title":"Ovarian Cancer","volume":"622","year":"2002"},{"key":"2026041210220580000_2025.06.24.661170v1.27","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2019.4731"},{"key":"2026041210220580000_2025.06.24.661170v1.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.11.004"},{"key":"2026041210220580000_2025.06.24.661170v1.29","first-page":"1938","article-title":"A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity","volume":"25","year":"2020","journal-title":"Nature Medicine"},{"key":"2026041210220580000_2025.06.24.661170v1.30","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00928-9"},{"key":"2026041210220580000_2025.06.24.661170v1.31","first-page":"1","article-title":"Evaluating cell lines as tumour models by comparison of genomic profiles","volume":"4","year":"2013","journal-title":"Nature Communications"},{"key":"2026041210220580000_2025.06.24.661170v1.32","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00127-7"},{"key":"2026041210220580000_2025.06.24.661170v1.33","doi-asserted-by":"crossref","unstructured":"Fraser, C. , Ryan, J. & Sarosiek, K. BH3 Profiling: A Functional Assay to Measure Apoptotic Priming and Dependencies. in Methods in Molecular Biology vol. 1877 61\u201376 (2019).","DOI":"10.1007\/978-1-4939-8861-7_4"},{"key":"2026041210220580000_2025.06.24.661170v1.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.08.038"},{"key":"2026041210220580000_2025.06.24.661170v1.35","doi-asserted-by":"crossref","unstructured":"Davids, M. S. et al. Mitochondrial Apoptotic Priming Is Associated with Clinical Response to the Bcl-2 Antagonist ABT-199 in Chronic Lymphocytic Leukemia. Blood 124, (2014).","DOI":"10.1182\/blood.V124.21.1940.1940"},{"key":"2026041210220580000_2025.06.24.661170v1.36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33461-z"},{"key":"2026041210220580000_2025.06.24.661170v1.37","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd5393"},{"key":"2026041210220580000_2025.06.24.661170v1.38","doi-asserted-by":"publisher","DOI":"10.1101\/720243"},{"key":"2026041210220580000_2025.06.24.661170v1.39","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-1467"},{"key":"2026041210220580000_2025.06.24.661170v1.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2022.01.021"},{"key":"2026041210220580000_2025.06.24.661170v1.41","doi-asserted-by":"publisher","DOI":"10.1080\/19466315.2018.1437071"},{"key":"2026041210220580000_2025.06.24.661170v1.42","doi-asserted-by":"crossref","unstructured":"Gillet, J.-P. , Varma, S. & Gottesman, M. M . The clinical relevance of cancer cell lines. Journal of the National Cancer Institute 105, (2013).","DOI":"10.1093\/jnci\/djt007"},{"key":"2026041210220580000_2025.06.24.661170v1.43","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1186-3"},{"key":"2026041210220580000_2025.06.24.661170v1.44","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-0474"},{"key":"2026041210220580000_2025.06.24.661170v1.45","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1237"},{"key":"2026041210220580000_2025.06.24.661170v1.46","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-006742"},{"key":"2026041210220580000_2025.06.24.661170v1.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.05.040"},{"key":"2026041210220580000_2025.06.24.661170v1.48","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.6208"},{"key":"2026041210220580000_2025.06.24.661170v1.49","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00625-6"},{"key":"2026041210220580000_2025.06.24.661170v1.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.11.011"},{"key":"2026041210220580000_2025.06.24.661170v1.51","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn6579"},{"key":"2026041210220580000_2025.06.24.661170v1.52","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.27.15_suppl.3505"},{"key":"2026041210220580000_2025.06.24.661170v1.53","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa4642"},{"key":"2026041210220580000_2025.06.24.661170v1.54","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-24-0028"},{"key":"2026041210220580000_2025.06.24.661170v1.55","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00263-7"},{"key":"2026041210220580000_2025.06.24.661170v1.56","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-398834"},{"key":"2026041210220580000_2025.06.24.661170v1.57","doi-asserted-by":"crossref","unstructured":"Opferman, J. T . Unraveling MCL-1 degradation. Cell Death & Differentiation 13, (2006).","DOI":"10.1038\/sj.cdd.4401978"},{"key":"2026041210220580000_2025.06.24.661170v1.58","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.525"},{"key":"2026041210220580000_2025.06.24.661170v1.59","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-0140"},{"key":"2026041210220580000_2025.06.24.661170v1.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.10.008"},{"key":"2026041210220580000_2025.06.24.661170v1.61","doi-asserted-by":"publisher","DOI":"10.1038\/nature09779"},{"key":"2026041210220580000_2025.06.24.661170v1.62","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805019200"},{"key":"2026041210220580000_2025.06.24.661170v1.63","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2013-5485"},{"key":"2026041210220580000_2025.06.24.661170v1.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2017.02.001"},{"key":"2026041210220580000_2025.06.24.661170v1.65","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24481"},{"key":"2026041210220580000_2025.06.24.661170v1.66","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071659"},{"key":"2026041210220580000_2025.06.24.661170v1.67","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-0669"},{"key":"2026041210220580000_2025.06.24.661170v1.68","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00407-4"},{"key":"2026041210220580000_2025.06.24.661170v1.69","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-024-02621-x"},{"key":"2026041210220580000_2025.06.24.661170v1.70","doi-asserted-by":"crossref","unstructured":"Ryan, J. , Montero, J. , Rocco, J. & Letai, A . iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry. Biological Chemistry 0, (2016).","DOI":"10.1515\/hsz-2016-0107"},{"key":"2026041210220580000_2025.06.24.661170v1.71","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M500279-MCP200"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.06.24.661170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T17:22:14Z","timestamp":1776014534000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.06.24.661170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":71,"URL":"https:\/\/doi.org\/10.1101\/2025.06.24.661170","relation":{},"subject":[],"published":{"date-parts":[[2025,6,26]]},"subtype":"preprint"}}